Biocompatible Ionic Liquid-Mediated Micelles for Enhanced Transdermal Delivery of Paclitaxel
| Autor: | Muhammad Moniruzzaman, Korban Ali, Rahman Md Moshikur, Masahiro Goto, Rie Wakabayashi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
endocrine system
Materials science Paclitaxel Proton Magnetic Resonance Spectroscopy Skin Absorption Ionic Liquids Biocompatible Materials 02 engineering and technology Administration Cutaneous 010402 general chemistry 01 natural sciences Micelle Mice Surface-Active Agents chemistry.chemical_compound Drug Delivery Systems Dynamic light scattering In vivo Spectroscopy Fourier Transform Infrared Animals General Materials Science Solubility Micelles Transdermal Mice Inbred BALB C Sorbitan monolaurate 021001 nanoscience & nanotechnology Antineoplastic Agents Phytogenic 0104 chemical sciences chemistry Ionic liquid Biophysics Female Nanocarriers 0210 nano-technology |
| Zdroj: | ACS Applied Materials & Interfaces. 13:19745-19755 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.1c03111 |
| Popis: | Chemotherapeutic cytotoxic agents such as paclitaxel (PTX) are considered essential for the treatment of various cancers. However, PTX injection is associated with severe systemic side effects and high rates of patient noncompliance. Micelle formulations (MFs) are nano-drug delivery systems that offer a solution to these problems. Herein, we report an advantageous carrier for the transdermal delivery of PTX comprising a new MF that consists of two biocompatible surfactants: cholinium oleate ([Cho][Ole]), which is a surface-active ionic liquid (SAIL), and sorbitan monolaurate (Span-20). A solubility assessment confirmed that PTX was readily solubilized in the SAIL-based micelles via multipoint hydrogen bonding and cation-π and π-π interactions between PTX and SAIL[Cho][Ole]. Dynamic light scattering (DLS) and transmission electron microscopy revealed that in the presence of PTX, the MF formed spherical PTX-loaded micelles that were well-distributed in the range 8.7-25.3 nm. According to DLS, the sizes and size distributions of the micelle droplets did not change significantly over the entire storage period, attesting to their physical stability. In vitro transdermal assessments using a Franz diffusion cell revealed that the MF absorbed PTX 4 times more effectively than a Tween 80-based formulation and 6 times more effectively than an ethanol-based formulation. In vitro and in vivo skin irritation tests revealed that the new carrier had a negligible toxicity profile compared with a conventional ionic liquid-based carrier. Based on these findings, we believe that the SAIL[Cho][Ole]-based MF has potential as a biocompatible nanocarrier for the effective transdermal delivery of poorly soluble chemotherapeutics such as PTX. |
| Databáze: | OpenAIRE |
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