Is Sporothrix chilensis circulating outside Chile?
| Autor: | Rosely Maria Zancopé-Oliveira, Rejane Pereira Neves, Ertênia Paiva Oliveira, Vanessa Brito de Souza Rabello, Reginaldo Gonçalves de Lima-Neto, Carlos Alberto Tiburcio Valeriano, Cícero Pinheiro Inácio, Rodrigo Almeida-Paes, Manoel Marques Evangelista Oliveira |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Antifungal Agents RC955-962 Pathology and Laboratory Medicine Geographical locations 0302 clinical medicine Tubulin Sporothrix Schenckii Arctic medicine. Tropical medicine Medicine and Health Sciences Sporothrix schenckii Mycological Typing Techniques Amphotericin skin and connective tissue diseases Data Management Fungal Pathogens biology Antimicrobials Fungal Diseases Drugs Eukaryota Phylogenetic Analysis Phylogenetics Infectious Diseases Medical Microbiology Taxonomy (biology) Pathogens Public aspects of medicine RA1-1270 Brazil Research Article Antifungal Computer and Information Sciences medicine.drug_class 030231 tropical medicine Microbial Sensitivity Tests Mycology Fungus Microbiology Sporothrix pallida 03 medical and health sciences Microbial Control parasitic diseases medicine Humans Evolutionary Systematics Microbial Pathogens Taxonomy Pharmacology Antifungals Evolutionary Biology Sporothrix chilensis Sporotrichosis Sporothrix Organisms Fungi Public Health Environmental and Occupational Health Biology and Life Sciences Sequence Analysis DNA South America biology.organism_classification medicine.disease bacterial infections and mycoses 030104 developmental biology People and places |
| Zdroj: | PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0008151 (2020) PLoS Neglected Tropical Diseases |
| ISSN: | 1935-2735 1935-2727 |
| Popis: | Sporothrix chilensis is a mild-pathogenical specie of Sporothrix pallida complex, until now, known as restrict to Chile. Herein, we describe the first clinical isolates identified as S. chilensis in Brazil, preserved in the URM Culture Collection, by polyphasic taxonomy, and their respective antifungal profile of this emergent fungus. Author summary Fungi of the Sporothrix schenckii Complex are the causative agents of the sporotrichosis, subcutaneous mycosis that presents a massive global distribution. In this work, we perform a taxonomic review, by a poliphasic approach, of Sporothrix sp. isolates stored in the University of Recife Culture Collection (Micoteca URM), previously identified as Sporothrix schenckii by classic methods of taxonomic identification. In addition, we perform the method of broth microdilution, aiming to acquire the minimal inhibitory concentration of the standard antifungals (itraconazole and amphotericin B) against these isolates. By sequencing of the partial β-tub-encoding gene, we confirm the occurrence of S. schenckii, and identified four isolates as the S. pallida Complex component, S. chilensis. All the isolates were susceptible to the antifungals, except one, that shows resistance to amphotericin B. Our study demonstrated the first occurrence of S. chilensis in Brazil. Also, we provide the first data concerned the resistance profile of this specie for the choice antifungals in the sporotrichosis treatment, what will have important implications with this regard in the future. |
| Databáze: | OpenAIRE |
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