Effects of treatment with mineralocorticoids on late steps of aldosterone biosynthesis in the rat
| Autor: | Jürg Müller, Urs A. Hunziker |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Time Factors Hydrocortisone medicine.drug_class medicine.medical_treatment Sodium chemistry.chemical_element Endogeny Biochemistry Steroid chemistry.chemical_compound Endocrinology Corticosterone Internal medicine Adrenal Glands medicine Animals 18-Hydroxycorticosterone Desoxycorticosterone Aldosterone Potassium Deficiency Rats Kinetics medicine.anatomical_structure chemistry Zona glomerulosa Mineralocorticoid Fludrocortisone Potassium Serotonin |
| Zdroj: | Journal of steroid biochemistry. 8(1) |
| ISSN: | 0022-4731 |
| Popis: | Treatment of rats with either 9 α-fluorocortisol or deoxycorticosterone trimethyl acetate for two weeks resulted in a marked decrease in the conversion of tritiated corticosterone and deoxycorticosterone to 18-hydroxy corticosterone and aldosterone and, to a lesser extent, also in the conversion of added deoxycorticosterone and 11-deoxycortisol to 11 β-hydroxylated derivatives by incubated capsular adrenal tissue (‘zona glomerulosa’). It did not affect the rate of steroid 18- and 11 β-hydroxylations by the decapsulated portions (‘zona fasciculata-reticularis’) of the glands. When incubated with serotonin, capsular adrenals of mineralocorticoid-treated rats produced less aldosterone but more deoxycorticosterone from endogenous precursors than capsular adrenals of control animals. Such effects of mineralocorticoids were not observed in animals kept on a sodium-deficient diet. However, in rats kept on a potassium-deficient diet, the administration of either mineralocorticoid induced an additional decrease in the capsular adrenal conversion of tritiated corticosterone to 18-hydroxycorticosterone and aldosterone. According to these observations, mineralocorticoids decrease the activity of two enzymes involved in the late stages of aldosterone biosynthesis, i.e. zona glomerulosa 18-hydroxylase and 11 β-hydroxylase, by a yet unknown mechanism, which depends on an unrestricted sodium intake. Similar effects had been previously induced in rats by sodium loading or potassium restriction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|