Volumetric Evaluation of 3D Multi-Gradient-Echo MRI Data to Assess Whole Liver Iron Distribution by Segmental R2* Analysis: First Experience

Autor: Arthur P, Wunderlich, Holger, Cario, Stephan, Kannengießer, Veronika, Grunau, Lena, Hering, Michael, Götz, Meinrad, Beer, Stefan Andreas, Schmidt
Rok vydání: 2022
Předmět:
Zdroj: RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren. 195:224-233
ISSN: 1438-9010
1438-9029
DOI: 10.1055/a-1976-910
Popis: Purpose MR transverse relaxation rate R2* has been shown to be useful for monitoring liver iron overload. A sequence enabling acquisition of the whole liver in a single breath hold is now available, thus allowing volumetric hepatic R2* distribution studies. We evaluated the feasibility of computer-assisted whole liver segmentation of 3 D multi-gradient-echo MRI data, and compared whole liver R2* determination to analyzing only a single slice. Also, segmental R2* differences were studied. Materials and Methods The liver of 44 patients, investigated by multi-gradient echo MRI at 1.5 T, was segmented and divided into nine segments. Segmental R2* values were examined for all patients together and with respect to two criteria: average R2* values, and reason for iron overload. Correlation of single-slice and volumetric data was tested with Spearman’s rank test, segmental and group differences were evaluated by analysis of variance. Results Whole-liver R2* values correlated excellent to single slice data (p Conclusion Our results suggest inhomogeneous hepatic iron distribution. Low R2* in S1 may be explained by its special vascularization. Key Points Citation Format
Databáze: OpenAIRE
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