Amyloid and tau accumulation precede CSF production decline in normal aging
| Autor: | Arthur Messier, Miles C. Miller, Gerald D. Silverberg, Tom A. Saul, John A Duncan, Ilias N Caralopoulos, Samir Majmudar, Stephanie Slone, Conrad E. Johanson, Elizabeth Kenney |
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| Rok vydání: | 2009 |
| Předmět: |
0303 health sciences
medicine.medical_specialty Hematology Amyloid business.industry Fischer rat Normal aging 03 medical and health sciences Cellular and Molecular Neuroscience Blue dextran 0302 clinical medicine Endocrinology Developmental Neuroscience Neurology Internal medicine mental disorders Medicine business Neuroscience 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Cerebrospinal Fluid Research. 6 |
| ISSN: | 1743-8454 |
| DOI: | 10.1186/1743-8454-6-s1-s38 |
| Popis: | Background It has been shown that there is an age-related decrease in CSF production in the Fischer rat brain, and that this decrease follows the CNS deposition of amyloid rather than preceding it [1]. We have postulated that amyloid and Tau accumulation in normal aging is multi-factorial, combining early defects in the blood-brain barrier (BBB) efflux transport of amyloid beta-peptide (A-beta) with later changes in CSF production and turnover, as well as up-regulation of A-beta influx transport. |
| Databáze: | OpenAIRE |
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