The New Salicylate Derivative UR-1505 Modulates the Th2/Humoral Response in a Dextran Sodium Sulphate Model of Colitis That Resembles Ulcerative Colitis
| Autor: | Julio Gálvez, Mònica Comalada, Manuel Merlos, Antonio Zarzuelo, Dolors Balsa, Pedro Michelena, Isabel Ramis, Juan Román, Elvira Bailón |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Colon
Sodium Anti-Inflammatory Agents chemistry.chemical_element Pharmacology Inflammatory bowel disease chemistry.chemical_compound Th2 Cells medicine Animals Colitis biology Dextran Sulfate lcsh:RM1-950 Interleukin medicine.disease In vitro Salicylates Immunoglobulin A Rats Disease Models Animal Dextran lcsh:Therapeutics. Pharmacology chemistry Concanavalin A Immunoglobulin G Immunology biology.protein Molecular Medicine Cytokines Colitis Ulcerative Antibody |
| Zdroj: | Journal of Pharmacological Sciences, Vol 109, Iss 2, Pp 315-318 (2009) |
| ISSN: | 1347-8613 |
| Popis: | The aim of the present study was to evaluate the inmunomodulatory effects of UR-1505, a new salicylate derivative, on the T helper (Th)2 / humoral response produced during dextran sodium sulfate (DSS)-induced rat colitis. In the in vitro studies, UR-1505 (300 μM) inhibited both the production of interleukin (IL)-10 and IL-5 in concanavalin A (Con A)-activated splenocytes and the production of immunoglobulin (Ig) G and IgA by B-lymphocytes. However, in contrast to the in vitro results, the administration of UR-1505 (10 and 30 mg/kg per day) to rats with established DSS-colitis enhanced both IL-10 and IgA production, whereas it inhibited IgG production, thus ameliorating the intestinal inflammation. Keywords:: inflammatory bowel disease, B lymphocyte, Th2-cytokine |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|