Membrane Fusion-Mediated Gold Nanoplating of Red Blood Cell: A Bioengineered CT-Contrast Agent
| Autor: | Arunkumar Pitchaimani, Santosh Aryal, Tej B. Shrestha, David S. Biller, Deryl L. Troyer, Tuyen Duong Thanh Nguyen |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Chemistry Biomedical Engineering Lipid bilayer fusion Spleen 02 engineering and technology 021001 nanoscience & nanotechnology Vascular lumen Biomaterials 03 medical and health sciences Red blood cell 030104 developmental biology medicine.anatomical_structure Colloidal gold Drug delivery medicine In vitro study Delivery system 0210 nano-technology Biomedical engineering |
| Zdroj: | ACS biomaterials scienceengineering. 3(1) |
| ISSN: | 2373-9878 |
| Popis: | Red blood cells (RBCs) are the natural resident of the vascular lumen, therefore delivery of any agents within the vascular lumen could benefit by unique natural transporting features of RBCs. RBCs continuously circulate for ∼100 days before being sequestered in the spleen, they only extravasate at sites of vascular hemorrhage. Taking advantages of these features, we engineered RBC as a carrier in order to design a unique delivery system capable of delivering X-ray computed tomography (CT) contrast agents, gold nanoparticles (AuNPs), thereby acting as CT-contrast agent. A strategic membrane fusion technique was used to engineer the surface of RBC with gold nanoparticles in this in vitro study without altering its shape, size, and surface properties. |
| Databáze: | OpenAIRE |
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