Screening of traditionally used Lebanese herbs for neurological activities
| Autor: | Anna K. Jäger, Sam Medhat Salah |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Lavandula
Drug Evaluation Preclinical Nerve Tissue Proteins Pharmacognosy Salvia Pharmacology Drug Discovery Animals Humans Lebanon Medicinal plants Serotonin Plasma Membrane Transport Proteins Membrane Glycoproteins biology Plant Extracts Membrane Transport Proteins food and beverages Receptors GABA-A biology.organism_classification Rats Origanum syriacum Officinalis Artemisia Cholinesterase Inhibitors Medicine Traditional Nervous System Diseases Melissa officinalis Phytotherapy Protein Binding |
| Zdroj: | Journal of Ethnopharmacology. 97:145-149 |
| ISSN: | 0378-8741 |
| DOI: | 10.1016/j.jep.2004.10.023 |
| Popis: | In the recent decades the use of traditional medicine in Lebanon has increased. Aqueous, ethanol and ethyl acetate extracts of seven Lebanese plants that are used traditionally for neurological disorders as Alzheimer's disease, epilepsy and affective disorders as depression were tested for inhibition of acetylcholinesterase and affinity to the GABA A -benzodiazepine site and to the serotonin transporter. Ethyl acetate extracts of Salvia triloba , Lavandula officinalis , Origanum syriacum and Artemisia herba-alba exhibited weak activity in the acetylcholinesterase assay. None of the plants were active in the serotonin transporter assay. An ethanolic extract of Artemisia herba-alba had good affinity to the GABA A -benzodiazepine receptor site; ethanolic extracts of Melissa officinalis and Salvia triloba had moderate activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect