MicroRNAs as Biomarkers of Systemic Changes in Response to Endurance Exercise—A Comprehensive Review
Autor: | Ceren Eyileten, Lukasz A. Malek, Lukasz Zareba, Jolanta M. Siller-Matula, Salvatore De Rosa, Aleksandra Soplinska, Marek Postuła, Zofia Wicik, Daniel Jakubik |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Cardiac fibrosis Clinical Biochemistry cardiac fibrosis Inflammation Disease Review 030204 cardiovascular system & hematology Bioinformatics 03 medical and health sciences 0302 clinical medicine Fibrosis Endurance training medicine General fitness training lcsh:R5-920 microRNA business.industry cardiac hypertrophy Cardiac myocyte adaptive changes Adaptive response medicine.disease 030104 developmental biology medicine.symptom business lcsh:Medicine (General) endurance sport |
Zdroj: | Diagnostics, Vol 10, Iss 813, p 813 (2020) Diagnostics |
ISSN: | 2075-4418 |
Popis: | Endurance sports have an unarguably beneficial influence on cardiovascular health and general fitness. Regular physical activity is considered one of the most powerful tools in the prevention of cardiovascular disease. MicroRNAs are small particles that regulate the post-transcription gene expression. Previous studies have shown that miRNAs might be promising biomarkers of the systemic changes in response to exercise, before they can be detected by standard imaging or laboratory methods. In this review, we focused on four important physiological processes involved in adaptive changes to various endurance exercises (namely, cardiac hypertrophy, cardiac myocyte damage, fibrosis, and inflammation). Moreover, we discussed miRNAs’ correlation with cardiopulmonary fitness parameter (VO2max). After a detailed literature search, we found that miR-1, miR-133, miR-21, and miR-155 are crucial in adaptive response to exercise. |
Databáze: | OpenAIRE |
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