Autoimmunity in the Abdominal Aortic Aneurysm and its Association with Smoking
| Autor: | M. David Tilson |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
biology
business.industry Context (language use) medicine.disease medicine.disease_cause Fibrinogen Abdominal aortic aneurysm Nitric oxide Autoimmunity Pathogenesis chemistry.chemical_compound chemistry Antigen State-of-the-Art Review Immunology medicine biology.protein cardiovascular system Radiology Nuclear Medicine and imaging Surgery cardiovascular diseases Antibody business Cardiology and Cardiovascular Medicine medicine.drug |
| Zdroj: | AORTA. 5:159-167 |
| ISSN: | 2325-4637 |
| DOI: | 10.12945/j.aorta.17.693 |
| Popis: | Smoking increases the risk of abdominal aortic aneurysm (AAA) in both humans and mice, although the underlying mechanisms are not completely understood. An adventitial aortic antigen, AAAP-40, has been partially sequenced. It has motifs with similarities to all three fibrinogen chains and appears to be connected in evolution to a large family of proteins called fibrinogen-related proteins. Fibrinogen may undergo non-enzymatic nitration, which may result from exposure to nitric oxide in cigarette smoke. Nitration of proteins renders them more immunogenic. It has recently been reported that anti-fibrinogen antibody promotes AAA development in mice. Also, anti-fibrinogen antibodies are present in patients with AAA. These matters are reviewed in the overall context of autoimmunity in AAA. The evidence suggests that smoking amplifies an auto-immune reaction that is critical to the pathogenesis of AAA. |
| Databáze: | OpenAIRE |
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