A synthetic gamma-lactone group with beta-lactamase inhibitory and sporulation initiation effects
| Autor: | Zs. Gál, Á. Koncz, E. Deák, P. Kovács, István Szabó, I. BenkO, F. Hernádi, Gy. Barabás |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Bone Marrow Cells
Microbial Sensitivity Tests beta-Lactams Microbiology Colony-Forming Units Assay Lactones Mice Animals Pharmacology (medical) Beta-Lactamase Inhibitors Antibacterial agent Pharmacology chemistry.chemical_classification Spores Bacterial biology Dose-Response Relationship Drug Streptomyces griseus biology.organism_classification In vitro Anti-Bacterial Agents Infectious Diseases Enzyme Oncology Biochemistry chemistry Actinomycetales Antibacterial activity beta-Lactamase Inhibitors Bacteria Cell Division |
| Zdroj: | Journal of chemotherapy (Florence, Italy). 12(4) |
| ISSN: | 1120-009X |
| Popis: | Previous studies showed that some lactones have beta-lactamase inhibitory or antibacterial effects, others--like A-factor (a gamma-butyrolactone) and its derivatives--stimulate sporulation in Streptomyces griseus strains. Our experiments were aimed at exploring whether synthetic gamma-lactones had such effects. None of the seven gamma-lactones studied showed antibacterial activity, but two of them inhibited beta-lactamases isolated from various bacteria. These two gamma-lactones did not reduce colony formation of murine bone marrow cells in vitro, indicating that they were not toxic to proliferating mammalian cells. Four gamma-lactones, including the two inhibiting beta-lactamase, stimulated sporulation in the non-sporulating S. griseus bald 7 mutant. Further studies of gamma-lactones as potential inhibitors of beta-lactamase seem to be warranted. |
| Databáze: | OpenAIRE |
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