Oncogenic Hijacking of the PIN1 Signaling Network
| Autor: | Alessandro Zannini, Alessandra Rustighi, Elena Campaner, Giannino Del Sal |
|---|---|
| Přispěvatelé: | Zannini, A., Rustighi, A., Campaner, E., Del Sal, G. |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research ved/biology.organism_classification_rank.species Cancer therapy Tumor development and progression Cancer target therapy Organismal development Post-translational modification Prolyl-isomerase PIN1 Signal transduction Tissue integrity Review cancer target therapy Biology lcsh:RC254-282 prolyl-isomerase PIN1 03 medical and health sciences 0302 clinical medicine Model organism tumor development and progression ved/biology Mechanism (biology) organismal development lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Signaling network Biomarker 030104 developmental biology post-translational modification Oncology 030220 oncology & carcinogenesis Cancer cell PIN1 Neuroscience signal transduction tissue integrity |
| Zdroj: | Frontiers in Oncology Frontiers in Oncology, Vol 9 (2019) |
| ISSN: | 2234-943X |
| DOI: | 10.3389/fonc.2019.00094 |
| Popis: | Cellular choices are determined by developmental and environmental stimuli through integrated signal transduction pathways. These critically depend on attainment of proper activation levels that in turn rely on post-translational modifications (PTMs) of single pathway members. Among these PTMs, post-phosphorylation prolyl-isomerization mediated by PIN1 represents a unique mechanism of spatial, temporal and quantitative control of signal transduction. Indeed PIN1 was shown to be crucial for determining activation levels of several pathways and biological outcomes downstream to a plethora of stimuli. Of note, studies performed in different model organisms and humans have shown that hormonal, nutrient, and oncogenic stimuli simultaneously affect both PIN1 activity and the pathways that depend on PIN1-mediated prolyl-isomerization, suggesting the existence of evolutionarily conserved molecular circuitries centered on this isomerase. This review focuses on molecular mechanisms and cellular processes like proliferation, metabolism, and stem cell fate, that are regulated by PIN1 in physiological conditions, discussing how these are subverted in and hijacked by cancer cells. Current status and open questions regarding the use of PIN1 as biomarker and target for cancer therapy as well as clinical development of PIN1 inhibitors are also addressed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|