A high ratio of dietary n-6/n-3 polyunsaturated fatty acids is associated with increased risk of prostate cancer
| Autor: | Christina D. Williams, Jared D. Iraggi, Madeline G. McKeever, Kathryn A. Newman, Leah R. Gerber, Delores J. Grant, Brian Whitley, Loretta A. Taylor, Stephen J. Freedland, Cathrine Hoyo |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Oncology medicine.medical_specialty Endocrinology Diabetes and Metabolism Prostate cancer Endocrinology Dietary Fats Unsaturated Risk Factors Prostate Fatty Acids Omega-6 Surveys and Questionnaires Internal medicine Fatty Acids Omega-3 Confidence Intervals Odds Ratio medicine Humans Risk factor Unsaturated fatty acid Aged chemistry.chemical_classification Nutrition and Dietetics business.industry Prostatic Neoplasms Cancer Odds ratio Middle Aged medicine.disease Diet Prostate-specific antigen Logistic Models medicine.anatomical_structure chemistry Case-Control Studies business Polyunsaturated fatty acid |
| Zdroj: | Nutrition Research. 31:1-8 |
| ISSN: | 0271-5317 |
| DOI: | 10.1016/j.nutres.2011.01.002 |
| Popis: | Experimental studies suggest omega-3 (n-3) polyunsaturated fatty acids (PUFA) suppress and n-6 PUFA promote prostate tumor carcinogenesis. Epidemiologic evidence remains inconclusive. The objectives of this study were to examine the association between n-3 and n-6 PUFA and prostate cancer risk and determine if these associations differ by race or disease aggressiveness. We hypothesize that high intakes of n-3 and n-6 PUFA will be associated with lower and higher prostate cancer risk, respectively. A case-control study comprising 79 prostate cancer cases and 187 controls was conducted at the Durham VA Medical Center. Diet was assessed using a food frequency questionnaire. Logistic regression analyses were used to obtain odds ratios (ORs) and 95% confidence intervals (95% CI) for the associations between n-3 and n-6 PUFA intakes, the dietary ratio of n-6/n-3 fatty acids, and prostate cancer risk. Our results showed no significant associations between specific n-3 or n-6 PUFA intakes and prostate cancer risk. The highest dietary ratio of n-6/n-3 was significantly associated with elevated risk of high-grade (OR, 3.55; 95% CI, 1.18-10.69; P trend = 0.03), but not low-grade prostate cancer (OR, 0.95; 95% CI, 0.43-2.17). In race-specific analyses, an increasing dietary ratio of n-6/n-3 fatty acids correlated with higher prostate cancer risk among white men ( P trend = 0.05), but not black men. In conclusion, our findings suggest that a high dietary ratio of n-6/n-3 fatty acids may increase the risk of overall prostate cancer among white men and possibly increase the risk of high-grade prostate cancer among all men. |
| Databáze: | OpenAIRE |
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