Discovery of a new anilino- 3H-pyrrolo[3,2-f]quinoline derivative as potential anti-cancer agent

Autor:	V. Gasparotto, Ornella Gia, L. Dalla Via, Maria Grazia Ferlin
Jazyk:	angličtina
Rok vydání:	2008
Předmět:	Programmed cell death Hydrochloride Stereochemistry Antineoplastic Agents Apoptosis Antiproliferative activity Antimitotic effect Mass Spectrometry Flow cytometry chemistry.chemical_compound Cell Line Tumor Drug Discovery Pyrroquinoline derivative medicine Humans Topoisomerase II Inhibitors Enzyme Inhibitors Pharmacology medicine.diagnostic_test Chemistry Organic Chemistry Quinoline Cell Cycle Biological activity General Medicine Cell cycle Flow Cytometry DNA interaction Quinolines Spectrophotometry Ultraviolet DNA
Popis:	The newly synthesized 1-[4-(3H-pyrrolo[3,2-f]quinolin-9-ylamino)-phenyl]-ethanone hydrochloride showed high antiproliferative activity by mixed mechanisms of action. The compound acts by forming an intercalative complex with DNA and inhibiting DNA topoisomerase II (topo II) and by blocking the cell cycle in G2/M phase. Probable cell death by apoptosis is also suggested by flow cytometry analysis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ce2d9a94d2ac6b64f3441c728d6b40 http://hdl.handle.net/11577/2472070 Zobrazit plný text záznamu