Effects of tryptophan, a precursor for melatonin, on IVF outcomes and Doppler parameters
| Autor: | Ayşe Zehra Özdemir, Handan Celik, Sertaç Batioğlu, Bahattin Avci, Pervin Karli, Fatma Devran Bildircin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Cultural Studies
Linguistics and Language History medicine.medical_specialty Pregnancy business.industry Triptofan melatonin gebelik IVF-ICSI Tryptophan Ivf icsi medicine.disease Language and Linguistics Tryptophan melatonin pregnancy Melatonin symbols.namesake Endocrinology Health Care Sciences and Services Anthropology Internal medicine medicine symbols Sağlık Bilimleri ve Hizmetleri business Doppler effect medicine.drug |
| Zdroj: | Volume: 3, Issue: 2 97-101 Journal of Health Sciences and Medicine |
| ISSN: | 2636-8579 |
| Popis: | Aims: Melatonin is the most powerful antioxidant and protects sperm, oocyte and embryo against oxidative stress. The effect of tryptophan, which is the building block of melatonin, on follicular melatonin levels and IVF outcomes is unknown. The objective of this study was to investigate the effect of tryptophan administration, a precursor for melatonin, on the levels of intrafollicular melatonin with the aim to reveal the correlation between tryptophan and the total number and quality of oocytes as well as clinical pregnancy rates. In addition, we aimed to examine the effect of melatonin increased by tryptophan on uterine and ovarian blood flow. Methods: Out of 103 patients who applied to Ondokuzmayis University IVF clinic for IVF treatment, 51 patients were administered a 100 mg dose of tryptophan orally (Group A) and 50 control patients who were randomly selected did not receive tryptophan (Group B). Firstly, follicular melatonin levels were compared between Group A receiving tryptophan and Group B without tryptophan. Both groups were also compared according to the oocyte count, oocyte count, fertilized oocyte count, embryo count and pregnancy rates, ultimately. In addition, all patients were measured for uterine and ovarian artery blood flow by vaginal ultrasound on the day of OPU.. Results: There were no differences in age (32.16 ± 3.82 years vs 33.06 ± 4.44 years) (p = 0.276), BMI (28.45 ± 2.82 kg/m)2 vs 28.15 ± 3.03kg/m2 (p = 0.602) and peak estradiol levels (2451.69 ± 469.75 pg/ml vs 2420.26 ± 443.71 pg / ml) (p = 0.73) between the groups. Group A exhibited high levels of melatonin in the follicular fluid with a mean value of 259.8 pg/ml, whereas Group B had 91.3 pg/ml (p |
| Databáze: | OpenAIRE |
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