Association between Hcy levels and the CBS844ins68 and MTHFR C677T polymorphisms with essential hypertension
| Autor: | Lei Zhang, Jiang Cheng, Weijuan Cai, Fang Yang, Liang Yin |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Genetics
medicine.medical_specialty Linkage disequilibrium Homocysteine General Neuroscience Haplotype Articles General Medicine Biology Essential hypertension medicine.disease General Biochemistry Genetics and Molecular Biology Genotype frequency chemistry.chemical_compound Endocrinology chemistry Internal medicine Genotype medicine General Pharmacology Toxicology and Pharmaceutics Allele Allele frequency |
| Zdroj: | Biomedical Reports. 2:861-868 |
| ISSN: | 2049-9442 2049-9434 |
| DOI: | 10.3892/br.2014.357 |
| Popis: | The aim of the present study was to investigate the association between the homocysteine (Hcy) levels and polymorphisms of the CBS844ins68 and MTHFR C677T genes in essential hypertension (EH). The effects of the MTHFR C677T and CBS844ins68 haploid genotypes and the combined genotypes on EH and levels of Hcy were further explored. The polymorphisms of CBS844ins68 and MTHFR C677T genes in 200 EH and 200 normal tensive (NT) patients were detected using polymerase chain reaction-restriction fragment length polymorphism and analysis of the distribution of genotypes. An automated biochemical analyzer was used to measure the plasma Hcy levels and the clinical biochemistry data. The plasma Hcy levels in EH were significantly higher than those of the NT group (P0.05) between males and females. Two genotypes, deletion/deletion (DD) and deletion/insertion (DI), of the CBS844ins68 polymorphism were found in two groups with no clear differences in two genotypes and allele frequency distribution (P>0.05). There were significant differences in the three genotype frequencies (χ2=6.658, χ2=4.410, P0.05) and the CT and TT types were significantly higher compared to the CC genotype (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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