Relation of Heart Failure Hospitalization to Exposure to Fine Particulate Air Pollution
| Autor: | C. Arden Pope, Dale G. Renlund, Benjamin D. Horne, Heidi T May, Abdallah G. Kfoury |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Heart disease Fine particulate Air pollution Cumulative Exposure medicine.disease_cause Severity of Illness Index Risk Factors Air Pollution Utah Internal medicine Humans Medicine Aged Cardiopulmonary disease Aged 80 and over Heart Failure business.industry Environmental Exposure Middle Aged medicine.disease Confidence interval Hospitalization Cross-Sectional Studies Heart failure Circulatory system Cardiology Female Particulate Matter Cardiology and Cardiovascular Medicine business |
| Zdroj: | The American Journal of Cardiology. 102:1230-1234 |
| ISSN: | 0002-9149 |
| Popis: | Cardiopulmonary disease has been associated with particulate matter (PM) air pollution. There is evidence that exposure to elevated PM concentrations increases risk of acute ischemic heart disease events, alters cardiac autonomic function, and increases risk of arrhythmias. It is plausible, therefore, that PM exposure may exacerbate heart failure (HF). A case-crossover study design was used to explore associations between fine PM (PM(2.5): particles with an aerodynamic diameteror =2.5 microm) and 2,628 HF hospitalizations. Patients lived on Utah's Wasatch Front and were drawn from those hospitalized at Intermountain Healthcare facilities with a primary diagnosis of HF. A 14-day lagged cumulative moving average of 10 microg/m(3) PM(2.5) was associated with a 13.1% (95% confidence interval 1.3 to 26.2) increase in HF admissions. The strongest PM(2.5)-HF associations were for elderly patients who had previously been admitted for HF and who required only a short period of hospitalization. HF hospitalizations are associated with lagged cumulative exposure to PM(2.5) of approximately 2 weeks. In conclusion, particulate air pollution may play a role in precipitating acute cardiac decompensation in otherwise well-managed patients with HF, perhaps through effects of PM on myocardial ischemia, cardiac autonomic function, and/or arrhythmic effects. |
| Databáze: | OpenAIRE |
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