Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome

Autor: Xuefeng Huang, Yili Teng, Lili Yang, Xia Chen, Haiyan Yang, Peiyu Wang, Ya Chen, Liangshan Mu, Jiexue Pan, Rong Tang, Qianqian Chen
Rok vydání: 2018
Předmět:
Adult
medicine.medical_specialty
China
lcsh:QH471-489
endocrine system diseases
Reproductive medicine
Physiology
030209 endocrinology & metabolism
Hyperuricemia
urologic and male genital diseases
lcsh:Gynecology and obstetrics
Body Mass Index
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
medicine
Prevalence
lcsh:Reproduction
Humans
Testosterone
Sex hormones
lcsh:RG1-991
Polycystic ovary syndrome
Retrospective Studies
030219 obstetrics & reproductive medicine
Estradiol
business.industry
Research
Obstetrics and Gynecology
nutritional and metabolic diseases
Odds ratio
Luteinizing Hormone
medicine.disease
Polycystic ovary
female genital diseases and pregnancy complications
Uric Acid
Blood pressure
Cross-Sectional Studies
Reproductive Medicine
chemistry
Uric acid
Female
Follicle Stimulating Hormone
business
Body mass index
Developmental Biology
Hormone
Zdroj: Reproductive Biology and Endocrinology : RB&E
Reproductive Biology and Endocrinology, Vol 16, Iss 1, Pp 1-6 (2018)
ISSN: 1477-7827
Popis: Background The prevalecne of hyperuricemia in polycystic ovary syndrome (PCOS) is still uncertain. We aimed to investigate the prevalence of hyperuricemia in PCOS and to determine the influence of reproductive hormones on uric acid concentration. Methods This retrospective cross-sectional study was performed at a large reproductive medicine center. Between March 2007 and October 2016, a total of 1,183 women with PCOS and 10,772 women without PCOS were included. PCOS was diagnosed according to the Rotterdam criteria. Anthropometric parameters, blood pressure, uric acid, reproductive hormones, glucose and lipids were measured in all subjects. Results The serum uric acid (SUA) level was higher in women with PCOS than in women without PCOS. The prevalence of hyperuricemia in women with PCOS (25.48%) was significantly higher than that in women without PCOS (8.74%). Analysis stratified for age and body mass index (BMI) showed that both the SUA level and the prevalence of hyperuricemia were higher in women with PCOS of different age and BMI groups than in women without PCOS. After adjusting for age, BMI and estimated glomerular filtration rate (eGFR), logistic regression analysis revealed that the luteinizing/follicle-stimulating hormone (LH/FSH) ratio (odds ratio (OR) = 1.20, 95% CI = 1.01–1.43) and testosterone level (OR = 1.56, 95% CI = 1.27–1.90) were positively associated with the prevalence of hyperuricemia in females with PCOS. Conclusions The serum uric acid (SUA) level and the prevalence of hyperuricemia markedly increased in women with PCOS. The testosterone level was positively associated with the SUA level and the prevalence of hyperuricemia in females with PCOS.
Databáze: OpenAIRE
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