Sexually transmitted infections among HIV serodiscordant partners: A secondary analysis of HIV Prevention Trial Network 052
| Autor: | Myron S. Cohen, Victor Akelo, Emily Shava, José Henrique Pilotto, Mulinda Nyirenda, Ravindre Panchia, Maganizo Chagomerana, Suwat Chariyalertsak, Mina C. Hosseinipour, Sheela Godbole, Sharlaa Badal-Faesen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
HPTN 052 medicine.medical_specialty Sexually Transmitted Diseases Human immunodeficiency virus (HIV) Chlamydia trachomatis HIV Infections Dermatology urologic and male genital diseases medicine.disease_cause Gonorrhea 03 medical and health sciences 0302 clinical medicine Secondary analysis Environmental health Prevalence Humans Medicine Pharmacology (medical) 030212 general & internal medicine 030505 public health business.industry Public health Public Health Environmental and Occupational Health virus diseases Chlamydia Infections Antiretroviral therapy Neisseria gonorrhoeae female genital diseases and pregnancy complications Infectious Diseases Serodiscordant Female 0305 other medical science business |
| Zdroj: | International Journal of STD & AIDS. 32:1204-1211 |
| ISSN: | 1758-1052 0956-4624 |
| DOI: | 10.1177/09564624211030368 |
| Popis: | Sexually transmitted infections (STIs) remain a public health concern because of their interaction(s) with HIV. In the HPTN 052 study, STIs were evaluated in both HIV-positive index cases and their HIV-negative partners at enrollment and at yearly follow-up visits. Our definition for STI was based on any infection with Chlamydia trachomatis, Neisseria gonorrhoeae, syphilis, or Trichomonas vaginalis. We used log-binomial regression models to identify factors associated with prevalent STIs. Generalized estimating equation models with the Poisson distribution were used to compare STI incidence between HIV-positive index cases and HIV-negative partners. 8.1% of the participants had STIs at enrollment. The prevalence of STIs (8.9 vs. 7.2) was higher in HIV-positive index cases than HIV-negative partners. Being female (prevalence ratio (PR) = 1.61; 95% CI: 1.20–2.16) or unmarried (PR = 1.92; 95% CI: 1.17–3.14) was associated with prevalent STIs. Compared to HIV-negative male partners, HIV-positive female index cases had a higher risk of STI acquisition (incidence rate ratio (IRR) = 2.25; 95% CI: 1.70–2.97). While we are implementing HIV prevention interventions for HIV-negative people, we should also intensify targeted STI prevention interventions, especially among HIV-positive women. |
| Databáze: | OpenAIRE |
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