Hemodynamic and metabolic responses to moderate asphyxia in brain and skeletal muscle of late-gestation fetal sheep
| Autor: | D Peebles, R. Springett, S. R. G. Harding, Mark A. Hanson, James P. Newman |
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| Rok vydání: | 2000 |
| Předmět: |
Physiology
Central nervous system Ischemia Hemodynamics Gestational Age Hindlimb Biology Fetal Hypoxia Iliac Artery Electron Transport Complex IV Hemoglobins Pregnancy Physiology (medical) medicine Animals Muscle Skeletal Acid-Base Equilibrium Asphyxia Fetus Sheep Brain Skeletal muscle Anatomy Heart Rate Fetal Hydrogen-Ion Concentration Hypoxia (medical) medicine.disease Oxygen medicine.anatomical_structure Blood Circulation Female medicine.symptom Oxidation-Reduction Blood Chemical Analysis |
| Zdroj: | Journal of Applied Physiology. 88:82-90 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/jappl.2000.88.1.82 |
| Popis: | The purpose of this study was to investigate metabolic and hemodynamic responses in two fetal tissues, hindlimb muscle and brain, to an episode of acute moderate asphyxia. Near-infrared spectroscopy was used to measure changes in total hemoglobin concentration ([tHb]) and the redox state of cytochrome oxidase (COX) simultaneously in the brain and hindlimb of near-term unanesthetized fetal sheep in utero. Oxygen delivery (Do2) to, and consumption (V˙o2) by, each tissue was derived from the arteriovenous difference in oxygen content and blood flow, measured by implanted flow probes. One hour of moderate asphyxia ( n = 11), caused by occlusion of the maternal common internal iliac artery, led to a significant fall in Do2to both tissues and to a significant drop inV˙o2by the head. This was associated with an initial fall in redox state COX in the leg but an increase in the brain. [tHb], and therefore blood volume, fell in the leg and increased in the brain. These data suggest the presence of a fetal metabolic response to hypoxia, which, in the brain, occurs rapidly and could be neuroprotective. |
| Databáze: | OpenAIRE |
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