Influence of ESR1 Variants on Clinical Characteristics and Fibromyalgia Syndrome in Turkish Women
| Autor: | Ahmet Inanir, Serbulent Yigit, Nevin Karakus, Ayse Feyda Nursal, Habibe Sema Arslan |
|---|---|
| Přispěvatelé: | [Belirlenecek] |
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Fibromyalgia Turkey medicine.drug_class Turkish Endocrinology Diabetes and Metabolism Risk Assessment Gastroenterology Sex Factors Gene Frequency Risk Factors Fibromiyalgia syndrome Internal medicine Statistical significance Genotype medicine Humans Immunology and Allergy Genetic Predisposition to Disease Allele Allele frequency XbaI business.industry Estrogen Receptor alpha Genetic Variation estrogen receptor-alpha Pvull Middle Aged language.human_language Phenotype Fibromyalgia syndrome variant Estrogen language Female women business Estrogen receptor alpha |
| Zdroj: | Endocrine, Metabolic & Immune Disorders - Drug Targets. 21:1326-1332 |
| ISSN: | 1871-5303 |
| DOI: | 10.2174/1871530320666200910110915 |
| Popis: | Background: Fibromyalgia syndrome (FMS) is characterized by widespread musculoskeletal pain. It is more common in women than in men, and sex hormones may play a role in this predominance. Therefore, this research investigated the clinical findings among Turkish females and whether Estrogen-α (ESR1) gene variants are associated with FMS. Methods: A total of 219 individuals were enrolled in this study. ESR1 variants (PvuII/XbaI) were genotyped using PCR-RFLP methods. The results of the analyses were evaluated for statistical significance. Results: There was a significant association between the ESR1 PvuII and FMS risk among Turkish women. The ESR1 PvuII CC genotype and C allele were higher in the patients than those in the controls (p=0.021, p=0.007, respectively). A more statistically significant association was observed between the patients and the controls in terms of TT genotype vs. TC+CC genotypes (p=0.022). Also, there was a statistically significant association between the patients and the controls in terms of TT+TC genotype vs. CC genotypes (p =0.028). There was no significant association between patients and the control group concerning the genotype distribution and allele frequencies of ESR1 XbaI (p>0.05). Headache was seen more frequently in the XbaI GA genotype (p=0.025), while XbaI AA genotype was associated with dysmenorrhea in patients with FMS (p=0.041). Conclusion: Our results indicate that ESR1 PvuII/XbaI variants are possibly effective in the development of FMS and some clinical features. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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