PET-Based Human Dosimetry of 68 Ga-NODAGA-Exendin-4, a Tracer for β-Cell Imaging
| Autor: | Tom J.P. Jansen, Eric P. Visser, Mijke Buitinga, Marti Boss, Martin Gotthardt, Maarten Brom |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
business.industry
Other Research Radboud Institute for Health Sciences [Radboudumc 0] medicine.disease medicine.disease_cause Effective dose (radiation) 3. Good health 030218 nuclear medicine & medical imaging 03 medical and health sciences All institutes and research themes of the Radboud University Medical Center 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis TRACER Absorbed dose Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14] medicine Congenital hyperinsulinism Dosimetry Radiology Nuclear Medicine and imaging Pancreas Nuclear medicine business Hyperinsulinemic hypoglycemia Insulinoma |
| Zdroj: | The Journal of Nuclear Medicine (1978), 61, 1, pp. 112-116 The Journal of Nuclear Medicine (1978), 61, 112-116 |
| ISSN: | 2159-662X 0161-5505 |
| DOI: | 10.2967/jnumed.119.228627 |
| Popis: | 68Ga-NODAGA-exendin-4 is a promising tracer for β-cell imaging using PET/CT. Possible applications include preoperative visualization of insulinomas and discrimination between focal and diffuse forms of congenital hyperinsulinism. There is also a significant role for this tracer in extending our knowledge on the role of β-cell mass in the pathophysiology of type 1 and type 2 diabetes by enabling noninvasive quantification of tracer uptake as a measure for β-cell mass. Calculating radiation doses from this tracer is important to assess its safety for use in patients (including young children) with benign diseases and healthy individuals. Methods: Six patients with hyperinsulinemic hypoglycemia were included. After intravenous injection of 100 MBq of the tracer, 4 successive PET/CT scans were obtained at 30, 60, 120, and 240 min after injection. Tracer activity in the pancreas, kidneys, duodenum, and remainder of the body were determined, and time-integrated activity coefficients for the measured organs were calculated. OLINDA/EXM software, version 1.1, was applied to calculate radiation doses using the reference adult male and female models and to estimate radiation doses to children. Results: The mean total effective dose for adults was very low (0.71 ± 0.07 mSv for a standard injected dose of 100 MBq). The organ with the highest absorbed dose was the kidney (47.3 ± 10.2 mGy/100 MBq). The estimated effective dose was 2.32 ± 0.32 mSv for an injected dose of 20 MBq in newborns. This dose decreased to 0.77 ± 0.11 mSv/20 MBq for 1-y-old children and 0.59 ± 0.05 mSv for an injected dose of 30 MBq in 5-y-old children. Conclusion: Our human PET/CT-based dosimetric calculations show that the effective radiation doses from the novel tracer 68Ga-NODAGA-exendin-4 are very low for adults and children. The doses are lower than reported for other polypeptide tracers such as somatostatin analogs (2.1-2.6 mSv/100 MBq) and are beneficial for application as a research tool, especially when repeated examinations are needed. |
| Databáze: | OpenAIRE |
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