Simulated microgravity significantly altered metabolism in epidermal stem cells
| Autor: | Zheng-Yang Chen, Song Guo, Hong-Feng Yan, Shao-Bin Chai, Pei-Ming Sun, Yan Cui, Tao Zhang, Binbin Li, He-Ming Yang, Hong-Wei Sun, Jin-Lian Zhou, Nan Jiang, Jia-Qi Yang, Gang Hu, Bing-Xin Xu |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell type Cell growth Chemistry Simulated microgravity Cell Biology General Medicine Metabolism Membrane transport Article Epidermal stem cells Cell biology Metabolism pathway 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Metabolomics RCCS Cell culture 030220 oncology & carcinogenesis KEGG Stem cell Developmental Biology |
| Zdroj: | In Vitro Cellular & Developmental Biology. Animal |
| ISSN: | 1543-706X 1071-2690 |
| Popis: | Simulated microgravity can significantly affect various cell types and multiple systems of the human body, such as cardiovascular system, skeletal muscle system, and immune system, and is known to cause anemia and loss of electrolyte and fluids. Epidermal stem cells (EpSCs) were cultured in a rotary cell culture system (RCCS) bioreactor to simulate microgravity. The metabolites of EpSCs were identified by liquid chromatography-mass spectrometry (LC-MS). Compared with normal gravity (NG) group, a total of 57 different metabolites of EpSCs were identified (P 1), including lipids and lipid-like molecules (51 molecules), amino acids (5 molecules), nucleosides, nucleotides, and analogues (1 molecule). According to the partial least squares discriminant analysis (PLS-DA) score plot, a VIP > 1 and P |
| Databáze: | OpenAIRE |
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