Serum C-reactive protein relationship in high- versus low-virulence pathogens in the diagnosis of periprosthetic joint infection
| Autor: | Niklas Unter Ecker, Carl Haasper, Christian Lausmann, Eduardo M. Suero, Akos Zahar, Thorsten Gehrke, Nael Hawi, Mustafa Citak |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Reoperation 0301 basic medicine Microbiology (medical) medicine.medical_specialty Prosthesis-Related Infections Optimal cutoff Knee Joint 030106 microbiology Periprosthetic Virulence Context (language use) Microbiology Gastroenterology Young Adult 03 medical and health sciences Internal medicine medicine Humans Aged Retrospective Studies Receiver operating characteristic biology business.industry C-reactive protein Diagnostic marker General Medicine Middle Aged Draining sinus C-Reactive Protein 030104 developmental biology ROC Curve biology.protein Female Hip Joint business Biomarkers |
| Zdroj: | Journal of Medical Microbiology. 68:910-917 |
| ISSN: | 1473-5644 0022-2615 |
| DOI: | 10.1099/jmm.0.000958 |
| Popis: | Little is known about the relationship between the virulence of pathogens in periprosthetic joint infection (PJI) and C-reactive protein (CRP) levels. In this context, we assessed the performance of CRP for PJI. We collected the following data from 987 cases of total joint revision due to PJI and 386 cases of aseptic revision: age, gender, comorbidities, values for serum CRP, leukocytes, microbiology for preoperatively taken aspirations and at least 2 intraoperative biopsies, and presence or absence of a draining sinus. The mean CRP value in the PJI group was 50.2 mg l−1 (sd=62.2), while a lower CRP value of 11.6 mg l−1 (sd=25.3) was found in the control group. There were no significant differences for the CRP values between patients with and without draining sinus (P=0.4423). The difference in CRP between high-virulence and low-virulence micro-organisms was significant for both the hip and the knee (P |
| Databáze: | OpenAIRE |
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