The effects of aetiology on outcome in patients treated with cardiac resynchronization therapy in the CARE-HF trial

Autor: Carina Blomström-Lundqvist, T. Remp, John G.F. Cleland, Stefan Lönnerholm, Per Blomström, Bertil Andrén, Gerhard Wikström, Nick Freemantle
Rok vydání: 2008
Předmět:
Male
medicine.medical_specialty
medicine.medical_treatment
Myocardial Ischemia
Cardiac resynchronization therapy
1102 Cardiovascular Medicine And Haematology
Ischaemic
Statistics
Nonparametric
law.invention
Ventricular Dysfunction
Left
Randomized controlled trial
Clinical Research
law
Internal medicine
medicine
Humans
cardiovascular diseases
Aetiology
Ventricular dyssynchrony
Aged
Heart Failure
Analysis of Variance
Ejection fraction
Surrogate endpoint
business.industry
Cardiac Pacing
Artificial
Stroke Volume
Stroke volume
Middle Aged
Prognosis
medicine.disease
Defibrillators
Implantable
Dyssynchrony
Treatment Outcome
CARE-HF
Cardiovascular System & Hematology
Heart failure
Circulatory system
cardiovascular system
Cardiology
Female
Resynchronization
CARE-HF study investigators
Cardiology and Cardiovascular Medicine
business
Zdroj: European Heart Journal
ISSN: 1522-9645
0195-668X
DOI: 10.1093/eurheartj/ehn577
Popis: Aims Cardiac dyssynchrony is common in patients with heart failure, whether or not they have ischaemic heart disease (IHD). The effect of the underlying cause of cardiac dysfunction on the response to cardiac resynchronization therapy (CRT) is unknown. This issue was addressed using data from the CARE-HF trial. Methods and results Patients ( n = 813) were grouped by heart failure aetiology (IHD n = 339 vs. non-IHD n = 473), and the primary composite (all-cause mortality or unplanned hospitalization for a major cardiovascular event) and principal secondary (all-cause mortality) endpoints analysed. Heart failure severity and the degree of dyssynchrony were compared between the groups by analysing baseline clinical and echocardiographic variables. Patients with IHD were more likely to be in NYHA class IV (7.5 vs. 4.0%; P = 0.03) and to have higher NT-proBNP levels (2182 vs. 1725 pg/L), indicating more advanced heart failure. The degree of dyssynchrony was more pronounced in patients without IHD (assessed using mean QRS duration, interventricular mechanical delay, and aorta-pulmonary pre-ejection time). Left ventricular ejection fraction and left ventricular end-systolic volume improved to a lesser extent in the IHD group (4.53 vs. 8.50% and −35.68 vs. –58.52 cm3). Despite these differences, CRT improved all-cause mortality, NYHA class, and hospitalization rates to a similar extent in patients with or without IHD. Conclusion The benefits of CRT in patients with or without IHD were similar in relative terms in the CARE-HF study but as patients with IHD had a worse prognosis, the benefit in absolute terms may be greater.
Databáze: OpenAIRE
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