Spontaneous and recurrent subdural haematoma in a patient with May-Hegglin anomaly
| Autor: | John Anthony Doherty, Zaid Sarsam, Christopher P. Millward |
|---|---|
| Rok vydání: | 2023 |
| Předmět: |
medicine.medical_specialty
business.industry Hearing Loss Sensorineural Subdural haematoma Arteriovenous malformation Case Report General Medicine Aneurysm Ruptured medicine.disease Thrombocytopenia Surgery Aneurysm rupture 03 medical and health sciences Recurrent haemorrhage 0302 clinical medicine Hematoma Subdural 030220 oncology & carcinogenesis May–Hegglin anomaly Coagulopathy Medicine Humans Neurosurgery business 030217 neurology & neurosurgery |
| Zdroj: | BMJ Case Rep |
| ISSN: | 1757-790X |
| Popis: | Both acute and chronic subdural haematomas typically occur following trauma. Non-traumatic causes are less common, but aetiologies include arteriovenous malformation, intracranial aneurysm rupture, tumour-associated haemorrhage and coagulopathies. May-Hegglin anomaly is an example of a coagulopathy, which is caused by a mutation in the gene encoding non-muscle myosin heavy chain 9 (MYH9) and therefore falls into a group of diseases referred to as MYH9-related diseases (MYH9-RD). The symptomology of MYH9-RD is often mild, and patients tend to experience epistaxis, gingival bleeding and bruising. Life-threatening haemorrhage rarely occurs. In this short report, we describe a patient with known May-Hegglin anomaly who presented with a potentially life-threatening, spontaneous subdural haematoma requiring surgery on two occasions. This is only the second such report in the literature, and the first of spontaneous and recurrent haemorrhage in association with May-Hegglin anomaly. |
| Databáze: | OpenAIRE |
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