Can Interim 18F-FDG PET or Diffusion-Weighted MRI Predict End-of-Treatment Outcome in FDG-Avid MALT Lymphoma After Rituximab-Based Therapy?: A Preliminary Study in 15 Patients
| Autor: | Werner Dolak, Markus Raderer, Marius E. Mayerhoefer, Matthias Pones, Ingrid Simonitsch-Klupp, Ivo Rausch, Julius Lukas, Georgios Karanikas, Leonhard Müllauer, Kurt Kletter, Michael Weber, Barbara Kiesewetter |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Lung Neoplasms Antineoplastic Agents Breast Neoplasms Soft Tissue Neoplasms 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Stomach Neoplasms Interim Positron Emission Tomography Computed Tomography Multidetector Computed Tomography medicine Image Processing Computer-Assisted Humans Radiology Nuclear Medicine and imaging Prospective Studies Prospective cohort study Aged medicine.diagnostic_test Lacrimal Apparatus Diseases business.industry Eye Neoplasms Splenic Neoplasms Remission Induction Magnetic resonance imaging MALT lymphoma General Medicine Lymphoma B-Cell Marginal Zone Middle Aged medicine.disease Prognosis Lymphoma Diffusion Magnetic Resonance Imaging Treatment Outcome Positron emission tomography 030220 oncology & carcinogenesis Positron-Emission Tomography Rituximab Female Immunotherapy Lymph Nodes Radiopharmaceuticals business Nuclear medicine Progressive disease medicine.drug |
| Zdroj: | Clinical nuclear medicine. 41(11) |
| ISSN: | 1536-0229 |
| Popis: | PURPOSE To determine whether interim F-FDG PET or interim diffusion-weighted magnetic resonance imaging (DWI) can predict the end-of-treatment (EOT) outcome after immunotherapy in patients with FDG-avid extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT). MATERIALS AND METHODS Patients with untreated MALT lymphoma prospectively underwent whole-body F-FDG PET/CT and DWI before treatment (baseline), and after three cycles (interim) of rituximab-based immunotherapy. Maximum and mean standardized uptake values (SUVmax, SUVmean), and minimum and mean apparent diffusion coefficients (ADCmin, ADCmean), were measured for up to three target lesions per patient. Rates of change between baseline and interim examinations (ΔSUVmax, ΔSUVmean, ΔADCmin, and ΔADCmean) were compared, using ANOVAs, between the four end-of-treatment (EOT, after six cycles of immunotherapy) outcomes: complete remission (CR), partial remission (PR), stable disease (SD), or progressive disease (PD). RESULTS Fifteen patients with 25 lesions were included. Lesion-based post hoc tests showed significant differences between CR and PR for ΔSUVmax (P < 0.001), ΔSUVmean (P < 0.001), and ΔADCmin (P = 0.044), and between CR and SD for ΔSUVmax (P < 0.001), ΔSUVmean (P < 0.001), ΔADCmin (P = 0.021), and ΔADCmean (P = 0.022). No lesion showed PD at EOT. CONCLUSIONS Both quantitative interim F-FDG PET and interim DWI may possibly be useful to predict complete remission at end-of-treatment in MALT lymphoma patients after immunotherapy. |
| Databáze: | OpenAIRE |
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