The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan
| Autor: | Andreas M. Brandmaier, Øystein Sørensen, Cristina Solé-Padullés, Dídac Macià, Matthew S. Panizzon, René Westerhausen, William S. Kremen, Håkon Grydeland, Jeremy A. Elman, Ulman Lindenberger, Simone Kühn, Stine K. Krogsrud, David Bartrés-Faz, Inge K Amlien, Anders M. Fjell, Tim C. Kietzmann, Yunpeng Wang, Carol E. Franz, Asta Håberg, Kristine B. Walhovd, Rogier A. Kievit, Sandra Düzel, Lars Nyberg, Athanasia M. Mowinckel |
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| Přispěvatelé: | Fjell, Anders Martin [0000-0003-2502-8774], Bartres-Faz, David [0000-0001-6020-4118], Brandmaier, Andreas M [0000-0001-8765-6982], Kievit, Rogier Andrew [0000-0003-0700-4568], Kühn, Simone [0000-0001-6823-7969], Lindenberger, Ulman [0000-0001-8428-6453], Mowinckel, Athanasia Monika [0000-0002-5756-0223], Nyberg, Lars [0000-0002-3367-1746], Apollo - University of Cambridge Repository |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Aging Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] neuroscience 0302 clinical medicine 80 and over Research article genetics Biology (General) Child Pediatric Aged 80 and over Cerebral Cortex Phylogenetic tree General Neuroscience Cognition General Medicine Cognitive artificial intelligence Middle Aged Magnetic Resonance Imaging 3. Good health medicine.anatomical_structure Cerebral cortex Child Preschool Neurological Medicine Female lifespan Research Article Human Adult Adolescent QH301-705.5 Science brain Longevity Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Young Adult All institutes and research themes of the Radboud University Medical Center medicine Genetics Humans human Preschool Aged Embryonic brain General Immunology and Microbiology Neurosciences Brain Disorders 030104 developmental biology Evolutionary biology Biochemistry and Cell Biology 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | Elife, 10 eLife, Vol 10 (2021) eLife |
| ISSN: | 2050-084X |
| Popis: | Contains fulltext : 235500.pdf (Publisher’s version ) (Open Access) Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ontogenetic and phylogenetic principles. We tested the hypothesis that genetically governed neurodevelopmental processes can be traced throughout life by assessing to which degree brain regions that develop together continue to change together through life. Analyzing over 6000 longitudinal MRIs of the brain, we used graph theory to identify five clusters of coordinated development, indexed as patterns of correlated volumetric change in brain structures. The clusters tended to follow placement along the cranial axis in embryonic brain development, suggesting continuity from prenatal stages, and correlated with cognition. Across independent longitudinal datasets, we demonstrated that developmental clusters were conserved through life. Twin-based genetic correlations revealed distinct sets of genes governing change in each cluster. Single-nucleotide polymorphisms-based analyses of 38,127 cross-sectional MRIs showed a similar pattern of genetic volume-volume correlations. In conclusion, coordination of subcortical change adheres to fundamental principles of lifespan continuity and genetic organization. 22 p. |
| Databáze: | OpenAIRE |
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