Effect of Temperature Extremes and Cortisone on Toxicity of Diphosphopyridine Nucleotide in Mice

Autor:	Haydu Gg, Wolfson Ah
Rok vydání:	1959
Předmět:	Nicotinamide Chemistry Coenzymes Temperature Reserpine NAD General Biochemistry Genetics and Molecular Biology Cortisone Mice chemistry.chemical_compound Biochemistry Toxicity medicine Animals Diphosphopyridine Nucleotide medicine.drug Promazine
Zdroj:	Experimental Biology and Medicine. 102:325-327
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-102-25234
Popis:	Summary1. DPN injection produces toxic effects in mice similar to those described for nicotinamide analogs. 2. Toxicity of injected DPN is influenced by environmental temperatures; both cold and hot environment enhances toxicity. 3. Simultaneous cortisone potentiates the effect of heat and cold. 4. These effects are discussed as they bear on inhibition of DPN-ase activity of reserpine, promazine and nicotinamide.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b6be5deb60233048058f773e6292e1 https://doi.org/10.3181/00379727-102-25234 Zobrazit plný text záznamu