Multigenic evasion of inflammation by poxviruses
| Autor: | W C Glasgow, R. M. L. Buller, Giuseppe Palumbo |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Leukotrienes
Genes Viral viruses Immunology Mutant Vaccinia virus Chick Embryo Orthopoxvirus Biology Kidney Microbiology Virus Cell Line Viral Proteins Cytopathogenic Effect Viral Allantois Virology Chlorocebus aethiops Animals Poxviridae Cowpox virus Gene Serpins Inflammation Arachidonic Acid Virulence Chorion biology.organism_classification Chordopoxvirinae Viral replication Insect Science Research Article |
| Zdroj: | Journal of Virology. 68:1737-1749 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.68.3.1737-1749.1994 |
| Popis: | Analyses of different cowpox virus (Brighton Red strain [CPV-BR]) mutants indicate that there is a minimum of three genes encoded by CPV-BR that are nonessential for virus replication in tissue culture but are involved in inhibiting the generation of an inflammatory response in the chicken embryo chorioallantoic membrane (CAM) model. The CPV-BR-encoded anti-inflammatory genes include the gene encoding the 38-kDa protein (also called 38K, crmA, SPI-2, or VV-WR-ORF-B13R), a tumor necrosis factor receptor homolog, and an unidentified gene that maps to the right end of the CPV genome. The kinetics of triggering of an inflammatory response at the site of virus infection as well as the magnitude of the response is dependent on the virus-encoded inhibitor that is deleted. Virus yields recovered from pocks decreased in proportion to the magnitude of the inflammatory response. The deletion of these identified inhibitors of inflammation was associated with attenuation of the mutant viruses in mice. These data confirm the existence of multiple poxvirus-encoded host defense modifiers whose function is to block the generation of an inflammatory response at the site of virus infection, which allows enhanced virus replication and potentially facilitates virus transmission. |
| Databáze: | OpenAIRE |
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