Humoral and cell-mediated immune responses to an early 2-dose measles vaccination regimen in the United States
| Autor: | Ross DeHovitz, Linda L. Yasukawa, Judith Beeler, Hayley A. Gans, Susette Audet, Mary Rinki, Ann M. Arvin, Amanda Alderson, Yvonne Maldonado |
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| Rok vydání: | 2003 |
| Předmět: |
Measles-Mumps-Rubella Vaccine
T-Lymphocytes Measles Vaccine Antibodies Viral Lymphocyte Activation Measles Measles virus Immunity Immunology and Allergy Medicine Humans Seroconversion Immunization Schedule biology business.industry Vaccination Antibody titer Infant biology.organism_classification medicine.disease Infectious Diseases Treatment Outcome Immunology Measles vaccine business |
| Zdroj: | The Journal of infectious diseases. 190(1) |
| ISSN: | 0022-1899 |
| Popis: | Shifts in peak measles incidence to children12 months old and the associated high mortality support the study of an early 2-dose measles vaccine regimen.Fifty-five infants were vaccinated with measles vaccine at age 6 (n=32) or 9 (n=23) months, followed by measles-mumps-rubella (MMR)-II vaccine at age 12 months. A control group received MMR-II only at age 12 months. Measles-specific humoral and cell-mediated immunity were evaluated before, 12 weeks after measles immunization, and 24 weeks after MMR-II.Measles-specific T cell proliferation after both doses of vaccine was equivalent, regardless of age or the presence of passive antibodies. Seroconversion rates, geometric mean titers, and the percentage of infants with antibody titers120 mIU after the first measles vaccine were lower in infants vaccinated at age 6 months, regardless of the presence of passive antibodies, but measles humoral responses increased after the administration of MMR-II vaccine in children initially vaccinated at age 6 or 9 months.Measles vaccination elicits T cell responses in infants as young as 6 months old, which may prime the humoral response to the second dose. Initiating measles vaccination as an early 2-dose regimen results in an immunologic response that is likely to have clinical benefits in developed and developing countries. |
| Databáze: | OpenAIRE |
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