Cross-border spread of blaNDM-1- and blaOXA-48-positive Klebsiella pneumoniae: a European collaborative analysis of whole genome sequencing and epidemiological data, 2014 to 2019
| Autor: | Te-Din Huang, Marc Struelens, Sören Gatermann, Agnès B Jousset, Felix Lötsch, Erik Alm, Sebastian Haller, Monica Monaco, Mateja Pirs, Jesús Oteo-Iglesias, Daniel Palm, Ørjan Samuelsen, Jari Jalava, Maria Del Grosso, Petra Edquist, Wendy Brennan, Henrik Hasman, Karin Johansson, Leo M. Schouls, Tjaša Cerar, Dominique L Monnet, Kati Räisänen, Laurent Dortet, Olivier Denis, Katie L. Hopkins, Narender Kumar, Anette M. Hammerum, Anke Kohlenberg, Martin Cormican, Karin Sjöström, Catherine Ludden, Barbara Albiger, María Pérez-Vázquez |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Epidemiology Klebsiella pneumoniae 030106 microbiology Sequencing data Microbial Sensitivity Tests NDM-1 beta-Lactamases Disease Outbreaks 03 medical and health sciences carbapenemase 0302 clinical medicine Antibiotic resistance Bacterial Proteins Virology medicine media_common.cataloged_instance Humans 030212 general & internal medicine European union VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Lungesykdommer: 777 Klebsiella pneumonia OXA-48 media_common Genetics Whole genome sequencing whole genome sequencing biology Public Health Environmental and Occupational Health Emigration and Immigration biochemical phenomena metabolism and nutrition medicine.disease biology.organism_classification Anti-Bacterial Agents Klebsiella Infections Geography Carbapenem-Resistant Enterobacteriaceae Carbapenems VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Lung diseases: 777 surveillance cross-border import OXA-48 NDM-1 carbapenem-resistant Enterobacterales Rapid Communication geographic locations |
| Zdroj: | Repisalud Instituto de Salud Carlos III (ISCIII) Eurosurveillance |
| Popis: | An alert regarding an outbreak of carbapenem-resistant Klebsiella pneumoniae carrying bla NDM-1 and bla OXA-48 carbapenemase-encoding genes was sent by Germany to European Union (EU)/European Economic Area (EEA) countries in October 2019. Since only limited whole genome sequencing (WGS) data on bla NDM-1- and bla OXA-48-positive K. pneumoniae were available in the public domain, national public health reference or equivalent expert laboratories from EU/EEA countries were invited to share WGS data from their national collections with the European Centre for Disease Prevention and Control (ECDC) to investigate the international dissemination of this epidemic strain. The analysis identified a Finnish case with an isolate closely related to the German outbreak strain and with an epidemiological link to St. Petersburg, Russia. In addition, several other clusters of genetically related bla NDM-1- and bla OXA-48-positive K. pneumoniae unrelated to the German outbreak strain but affecting numerous EU/EEA countries were identified. The aim of this follow-up investigation was to characterise these clusters based on the integrated analysis of the WGS dataset on bla NDM-1 - and bla OXA-48-positive K. pneumoniae submitted from 13 EU/EEA countries and additional epidemiological data. |
| Databáze: | OpenAIRE |
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