CTLA-4 gene polymorphisms associate with efficacy of postoperative radioiodine-131 for differentiated thyroid carcinoma (Retracted)
| Autor: | Zhong-Qing Xu, Ya-Mei Sun, Jing Huang, De-Feng Chang, Xiao-Hong Chen, Da-Yong Zhu |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Ctla 4 gene Surgical resection Cancer Research medicine.medical_specialty Genotype Remnant ablation Kaplan-Meier Estimate Polymorphism Single Nucleotide Gastroenterology Iodine Radioisotopes Thyroid carcinoma 03 medical and health sciences 0302 clinical medicine Gene Frequency Recurrence Internal medicine medicine Humans CTLA-4 Antigen Thyroid Neoplasms Allele frequency Alleles Postoperative Care business.industry General Medicine Prognosis Combined Modality Therapy Treatment efficacy Treatment Outcome Endocrinology Oncology 030220 oncology & carcinogenesis Healthy individuals Female Neoplasm Grading business Biomarkers Follow-Up Studies 030215 immunology |
| Zdroj: | Future Oncology. 13:1057-1068 |
| ISSN: | 1744-8301 1479-6694 |
| DOI: | 10.2217/fon-2016-0399 |
| Popis: | Aim: To investigate the association of CTLA-4 polymorphisms with efficacy of postoperative radioiodine-131 (I-131) treatment for differentiated thyroid carcinoma (DTC). Methods: A total of 324 DTC patients and 350 healthy individuals were enrolled in our study. Patients received I-131 remnant ablation following surgical resection. Based on the treatment efficacy, patients were divided into the effective (n = 183) and ineffective groups (n = 141). CTLA-4 polymorphisms (+49A>G, CT60A>G and -318C>T) were genotyped by polymerase chain reaction-restriction fragment length polymorphism. Results: AG + AA genotype distribution and A allele frequency of +49A>G and CT60A>G polymorphisms were higher in the effective group than the ineffective group. Conclusion: +49A>G and CT60A>G polymorphisms were associated with the efficacy of postoperative I-131 treatment for DTC; and they might be bioindicators related to the prognosis of I-131 treatment. |
| Databáze: | OpenAIRE |
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