Elevated morning serum interleukin (IL)-6 or evening salivary cortisol concentrations predict posttraumatic stress disorder in children and adolescents six months after a motor vehicle accident
| Autor: | Spyros Ferentinos, Chrysa Bakoula, Gerasimos Kolaitis, George P. Chrousos, Panagiota Pervanidou, Ioannis Papassotiriou, Stella Charitaki, John Tsiantis, Alexandra Margeli, Christina Lazaropoulou |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Evening Adolescent Hydrocortisone Endocrinology Diabetes and Metabolism Poison control Physiology Stress Disorders Post-Traumatic Endocrinology Predictive Value of Tests Internal medicine medicine Humans Longitudinal Studies Prospective Studies Child Saliva Prospective cohort study Biological Psychiatry Morning Interleukin-6 Endocrine and Autonomic Systems Accidents Traffic Interleukin Prognosis medicine.disease Circadian Rhythm Motor Vehicles Psychiatry and Mental health Cross-Sectional Studies Case-Control Studies Female Psychology Anxiety disorder Glucocorticoid medicine.drug |
| Zdroj: | Psychoneuroendocrinology. 32:991-999 |
| ISSN: | 0306-4530 |
| DOI: | 10.1016/j.psyneuen.2007.07.001 |
| Popis: | This study examined prospectively the activity of the hypothalamic-pituitary-adrenal axis, the sympathetic nervous system and inflammatory factors in children shortly after a motor vehicle accident (MVA) in relation to later posttraumatic stress disorder (PTSD) development.Fifty six children, aged 7-18, were studied after an MVA and 1 and 6 months later; 40 subjects served as controls. Morning serum cortisol and interleukin (IL)-6 and plasma catecholamine concentrations were measured within 24h after the event. Salivary cortisol was measured 5 times at defined time points during the same day. PTSD diagnoses 1 and 6 months later were based on K-SADS interview.Morning serum IL-6 concentrations, measured within the first 24h after the accident, were higher in children that developed PTSD 6 months later than those who did not and those of the control group. Longitudinal IL-6 measurements revealed normalization of IL-6 in the PTSD group, while no differences between the three groups were detected 1 and 6 months later. Evening salivary cortisol and morning serum IL-6 after the accident were positively inter-related (r=0.54, p0.001) and in separate regression analyses both predicted PTSD development 6 months later. In contrast, morning serum IL-6 did nor correlate with morning serum or salivary cortisol concentrations.Immediate posttraumatic alterations in neuroendocrine or inflammatory factors-increased evening salivary cortisol and/or increased morning serum IL-6 concentrations-are involved in subsequent PTSD development in children and adolescents. |
| Databáze: | OpenAIRE |
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