Growth of Very Low Birth Weight Infants Who Received a Liquid Human Milk Fortifier: A Randomized, Controlled Multicenter Trial
| Autor: | Pamela Ramolfo, Patricia Mena, Miriam Faundes, Daniela Masoli, Patricia Vernal, Jose L. Tapia, Angélica Domínguez, Ricardo Uauy, Ruth Esparza, M E Hubner, Antonio Ríos, Miguel Angel Pantoja |
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| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Weight Gain law.invention Randomized controlled trial law Multicenter trial medicine Humans Infant Very Low Birth Weight Adverse effect Milk Human business.industry Incidence (epidemiology) High protein Gastroenterology Infant Newborn Infant medicine.disease Low birth weight Human milk fortifier Pediatrics Perinatology and Child Health Necrotizing enterocolitis Food Fortified medicine.symptom business Infant Premature |
| Zdroj: | Journal of pediatric gastroenterology and nutrition. 74(3) |
| ISSN: | 1536-4801 |
| Popis: | OBJECTIVES To evaluate growth (weight, length, head circumference, and knee-heel length [KHL]) in very low birth weight (VLBW) infants (500-1,500 g) who received human milk with a liquid fortifier (LHMF) with high protein and fatty acid content versus a traditional powder fortifier (PHMF) for 45 days or until discharge. METHODS This was a multicenter, randomized, controlled trial. An intention-to-treat analysis was performed to determine adverse events and withdrawal causes. We also performed an efficacy analysis involving the infants who completed at least 2 weeks of study. RESULTS Of the 158 infants enrolled in the study, 146 completed at least 2 weeks, and 125 completed the entire study. The biodemographic characteristics were similar between groups, with no differences in increments of weight (22.9 vs. 22.7 g/kg/day), length (1.03 vs. 1.09 cm/week), head circumference (0.91 vs. 0.90 cm/week), or KHL (3.6 vs. 3.3 mm/week). The KHL increment was greater in infants weighing >1 kg receiving LHMF (3.7 vs. 3.2 mm/week p = 0.027). Although there were no significant differences in serious adverse events, the incidence difference of the composite outcome death/necrotizing enterocolitis between groups warrants attention (1.3% with LHMF and 8.1% with PHMF). CONCLUSION There were no differences in the overall growth between VLBW infants receiving either fortifier. |
| Databáze: | OpenAIRE |
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