Increased cocaine and amphetamine-regulated transcript cord blood levels in the newborns exposed to crack cocaine in utero

Autor: Maria Lucrécia Scherer Zavaschi, Claudia Maciel Szobot, Keila Maria Mendes Ceresér, Victor Mardini, Carolina Gubert, Flavio Pechansky, Luis Augusto Paim Rhode, Fernando Antonio Costa Xavier, Daniel D. Langleben, Rodrigo Ritter Parcianello
Rok vydání: 2017
Předmět:
Zdroj: Psychopharmacology. 235:215-222
ISSN: 1432-2072
0033-3158
DOI: 10.1007/s00213-017-4759-6
Popis: Cocaine and amphetamine-regulated transcript (CART) is an endogenous antioxidant present since the embryonic period. CART is activated by high levels of dopamine and might be of interested in understanding the changes in the REDOX system associated with crack/cocaine intake. The goal of this study was to determine whether exposure to crack in utero is associated with increased CART levels. In this cross-sectional study with consecutive sampling, we compared the umbilical cord blood (UCB) CART levels (μg/mL) of newborns exposed to crack/cocaine in utero (EN, n = 57) to levels in non-exposed newborns (NEN, n = 99). In addition, we compared serum CART levels between EN and NEN mothers, in the immediate postpartum period. Potential confounders, such as perinatal data (e.g., weight, Apgar, etc.), psychopathology (DSM-IV), and use of drugs other than crack (ASSIST) were assessed. According to general linear model analysis, the adjusted mean CART was significantly higher in EN (0.180, 95% CI 0.088–0.272) than in NEN (0.048, 95% CI 0.020–0.076; p
Databáze: OpenAIRE
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