RNA Polymerase Inhibitors with Activity against Rifampin-Resistant Mutants of Staphylococcus aureus

Autor: Christopher Storey, Ian Chopra, Colin W. G. Fishwick, Anthony M. Hoyle, Brunello Oliva, Alex J. O'Neill
Rok vydání: 2000
Předmět:
Zdroj: Antimicrobial Agents and Chemotherapy. 44:3163-3166
ISSN: 1098-6596
0066-4804
DOI: 10.1128/aac.44.11.3163-3166.2000
Popis: A collection of rifampin-resistant mutants of Staphylococcus aureus with characterized RNA polymerase β-subunit ( rpoB ) gene mutations was cross-screened against a number of other RNA polymerase inhibitors to correlate susceptibility with specific rpoB genotypes. The rpoB mutants were cross-resistant to streptolydigin and sorangicin A. In contrast, thiolutin, holomycin, corallopyronin A, and ripostatin A retained activity against the rpoB mutants. The second group of inhibitors may be of interest as drug development candidates.
Databáze: OpenAIRE