RNA Polymerase Inhibitors with Activity against Rifampin-Resistant Mutants of Staphylococcus aureus
Autor: | Christopher Storey, Ian Chopra, Colin W. G. Fishwick, Anthony M. Hoyle, Brunello Oliva, Alex J. O'Neill |
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Rok vydání: | 2000 |
Předmět: |
Staphylococcus aureus
Lactams Mutant Microbial Sensitivity Tests Gene mutation Biology medicine.disease_cause law.invention Microbiology Lactones chemistry.chemical_compound law RNA polymerase polycyclic compounds medicine Pharmacology (medical) Enzyme Inhibitors Antibiotics Antitubercular Polymerase chain reaction Pharmacology Drug Resistance Microbial DNA-Directed RNA Polymerases biochemical phenomena metabolism and nutrition bacterial infections and mycoses rpoB Molecular biology Thiolutin Pyrrolidinones Anti-Bacterial Agents Infectious Diseases chemistry Susceptibility bacteria Rifampin Streptolydigin medicine.drug |
Zdroj: | Antimicrobial Agents and Chemotherapy. 44:3163-3166 |
ISSN: | 1098-6596 0066-4804 |
DOI: | 10.1128/aac.44.11.3163-3166.2000 |
Popis: | A collection of rifampin-resistant mutants of Staphylococcus aureus with characterized RNA polymerase β-subunit ( rpoB ) gene mutations was cross-screened against a number of other RNA polymerase inhibitors to correlate susceptibility with specific rpoB genotypes. The rpoB mutants were cross-resistant to streptolydigin and sorangicin A. In contrast, thiolutin, holomycin, corallopyronin A, and ripostatin A retained activity against the rpoB mutants. The second group of inhibitors may be of interest as drug development candidates. |
Databáze: | OpenAIRE |
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