Circulating tumor cells as a surrogate marker for determining response to chemotherapy in Japanese patients with metastatic colorectal cancer
| Autor: | Kiyohiko Hatake, Mitsukuni Suenaga, Yuji Mishima, Nobuyuki Mizunuma, Ryoko Kuniyoshi, Yasuhito Terui, Satoshi Matsusaka, Koichi Takagi |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent Organoplatinum Compounds Colorectal cancer medicine.medical_treatment Antineoplastic Agents Gastroenterology Disease-Free Survival Circulating tumor cell Carcinoembryonic antigen Japan Internal medicine medicine Humans Prospective Studies Neoplasm Metastasis Prospective cohort study Aged Chemotherapy biology Surrogate endpoint business.industry Cancer General Medicine Middle Aged medicine.disease Neoplastic Cells Circulating digestive system diseases Oxaliplatin Carcinoembryonic Antigen Treatment Outcome Oncology biology.protein Disease Progression Female business Colorectal Neoplasms medicine.drug |
| Zdroj: | Cancer science. 102(6) |
| ISSN: | 1349-7006 |
| Popis: | The purpose of this study was to investigate the potential of circulating tumor cells (CTC) as a surrogate marker of the clinical outcome in metastatic colorectal cancer (mCRC) patients in order to identify Japanese patients responsive to oxaliplatin-based chemotherapy. Between January 2007 and April 2008, 64 patients with mCRC were enrolled in this prospective study. The treatment regimen was oxaliplatin-based chemotherapy. Collection of CTC from whole blood was performed at baseline and at 2 and 8–12 weeks after initiation of chemotherapy. Isolation and enumeration of CTC was performed using immunomagnetics. Patients with ≥3 CTC at baseline and at 2 and 8–12 weeks had a shorter median progression-free survival (8.5, 7.3 and 1.9 months, respectively) than those with |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text