Effects of digoxin on atrioventricular conduction patterns in man
| Autor: | Anthony N. Damato, Andrew C. Przybyla, Karlen L. Paulay, Emanuel Stein |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Adult
Male medicine.medical_specialty Digoxin Electrocardiography Heart Conduction System Internal medicine medicine Humans Ventricular conduction cardiovascular diseases Clinical Trials as Topic business.industry Atrioventricular conduction Atrial fibrillation Intraventricular conduction Middle Aged medicine.disease Surface electrocardiogram Heart Block Atrial depolarization Anesthesia cardiovascular system Cardiology Female Cardiology and Cardiovascular Medicine Sinoventricular conduction business medicine.drug |
| Zdroj: | The American journal of cardiology. 33(3) |
| ISSN: | 0002-9149 |
| Popis: | Digoxin was acutely administered to 17 patients, and its effects on atrioventricular (A-V) conduction were assessed. In the control state, before administration of digoxin, progressively premature atrial depolarization showed conduction delay and block confined solely to the A-V node in eight patients and to both the A-V node and the more distal His-Purkinje tissue in nine patients. His-Purkinje conduction delay was manifested on the surface electrocardiogram by ventricular aberration. After administration of digoxin, an early atrial premature impulse either was blocked in the A-V node or reached the distal intraventricular conduction system so late that block or conduction delay below the His bundle was reduced or no longer occurred. Ventricular aberration on the surface electrocardiogram was thus reduced or eliminated. These effects of digoxin on A-V conduction were due to its effect on the A-V node of slowing conduction of a premature impulse. Such action on the A-V node may abolish aberrant ventricular conduction in atrial fibrillation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|