Monte Carlo simulation and dosimetry measurements of an experimental approach for in vitro HDR brachytherapy irradiation
| Autor: | Arnoldo Mafra, Clascídia A. Furtado, Bruno Guilherme Gomes, Jony Marques Geraldo, Kennedy B. Gonçalves, Miguel T. T. Leite, Cássia T. Grundmann, Luiz O. Ladeira, Telma Cristina Ferreira Fonseca, Luciana Batista Nogueira, Lídia M. Andrade |
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| Rok vydání: | 2020 |
| Předmět: |
Radiation
Materials science medicine.medical_treatment Brachytherapy Monte Carlo method Radiotherapy Dosage In Vitro Techniques 010403 inorganic & nuclear chemistry 01 natural sciences High-Dose Rate Brachytherapy 030218 nuclear medicine & medical imaging 0104 chemical sciences Ionizing radiation 03 medical and health sciences Laboratory flask 0302 clinical medicine Planned Dose Ionization chamber medicine Dosimetry Humans Monte Carlo Method Biomedical engineering |
| Zdroj: | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 172 |
| ISSN: | 1872-9800 |
| Popis: | Irradiation of tumor cell lines is a useful way to investigate the effects of ionizing radiation on biological molecules. We designed an easy and reproducible approach for in vitro experimental high dose rate brachytherapy, which was simulated by a Monte Carlo code and dosimetrically characterized by experimental methods to evaluate the correspondence between planned doses and doses absorbed by the cells. This approach is an acrylic platform containing T25 tissue culture flasks and multiwell tissue culture plates. It allows nine parallel needles carrying an 192Ir source to irradiate the adherent cells. The whole system composed of the acrylic platform, tissue culture flasks and 192Ir source tracking was simulated by the Monte Carlo N-Particle transport code (MCNPX). Dosimetric measurements were taken by well ionization chamber and radiochromic films. There was a slight difference, averaging from 2% to 7%, between the MCNPX results and film dosimetry results regarding uniform radiation created by the source arrangement. The results showed different values for planned and measured doses in each cell culture plate, which was attributed to the non-equivalent water material used and to the lack of full scattering coming from the top of the platform. This last contribution was different for each tissue culture plate and an individual dose correction factor was calculated. The dose correction factor must be applied to match the planned dose and the actual doses absorbed by the cells. The designed approach is an efficient tool for in vitro brachytherapy experiments for most commercial cell culture plates. |
| Databáze: | OpenAIRE |
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