Fabrication of Anisotropic Cu Ferrite-Polymer Core-Shell Nanoparticles for Photodynamic Ablation of Cervical Cancer Cells
Autor: | Jing-Yin Huang, Chin-Pao Chiu, Po-Ting Wu, Mei-Yi Liao, Shuo-Hsiu Kuo, Jiashing Yu |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
inorganic chemicals
General Chemical Engineering medicine.medical_treatment Nanoparticle Photodynamic therapy Article cancer treatment HeLa lcsh:Chemistry Fenton reaction chemistry.chemical_compound medicine General Materials Science Photosensitizer Hydrogen peroxide reactive oxygen species bimetallic nanoparticles biology Singlet oxygen technology industry and agriculture biology.organism_classification superparamagnetic nanoparticles chemistry lcsh:QD1-999 photodynamic therapy Drug delivery Superparamagnetism Nuclear chemistry |
Zdroj: | Nanomaterials Volume 10 Issue 12 Nanomaterials, Vol 10, Iss 2429, p 2429 (2020) |
ISSN: | 2079-4991 |
DOI: | 10.3390/nano10122429 |
Popis: | In this work we developed methylene blue-immobilized copper-iron nanoparticles (MB-CuFe NPs) through a facile one-step hydrothermal reaction to achieve a better phototherapeutic effect. The Fe/Cu ratio of the CuFe NPs was controllable by merely changing the loading amount of iron precursor concentration. The CuFe NPs could serve as a Fenton catalyst to convert hydrogen peroxide (H2O2) into reactive oxygen species (ROS), while the superparamagnetic properties also suggest magnetic resonance imaging (MRI) potential. Furthermore, the Food and Drug Administration (FDA)-approved MB photosensitizer could strongly adsorb onto the surface of CuFe NPs to facilitate the drug delivery into cells and improve the photodynamic therapy at 660 nm via significant generation of singlet oxygen species, leading to enhanced cancer cell-damaging efficacy. An MTT (thiazolyl blue tetrazolium bromide) assay proved the low cytotoxicity of the CuFe NPs to cervical cancer cells (HeLa cells), namely above 80% at 25 ppm of the sample dose. A slight dissolution of Cu and Fe ions from the CuFe NPs in an acidic environment was obtained, providing direct evidence for CuFe NPs being degradable without the risk of long-term retention in the body. Moreover, the tremendous photo-to-thermal conversion of CuFe NPs was examined, which might be combined with photodynamic therapy (PDT) for promising development in the depletion of cancer cells after a single pulse of deep-red light irradiation at high laser power. |
Databáze: | OpenAIRE |
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