Effects of Three Cytokine Regimens on Hematologic Recovery and Progenitor Cell Mobilization after High-Dose Cyclophosphamide, Etoposide, and Cisplatin
| Autor: | Paola Stura, Alberto Ballestrero, Fabio Ferrando, Domenico Amoroso, Roberta Gonella, Anna Garuti, Mario Sessarego, Franco Patrone, Francesco Boccardo |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Cancer Research Neutropenia Cyclophosphamide medicine.medical_treatment Antigens CD34 Breast Neoplasms Adenocarcinoma Pharmacology Drug Administration Schedule Leukocyte Count chemistry.chemical_compound Antineoplastic Combined Chemotherapy Protocols Granulocyte Colony-Stimulating Factor medicine Humans Progenitor cell Etoposide Chemotherapy business.industry Granulocyte-Macrophage Colony-Stimulating Factor General Medicine Middle Aged Hematopoietic Stem Cells Thrombocytopenia Nitrogen mustard Granulocyte colony-stimulating factor Granulocyte macrophage colony-stimulating factor Oncology chemistry Toxicity Immunology Cytokines Female Interleukin-3 Cisplatin business medicine.drug |
| Zdroj: | Oncology. 59:7-13 |
| ISSN: | 1423-0232 0030-2414 |
| DOI: | 10.1159/000012129 |
| Popis: | The aim of this study was to compare both the effects on hematologic recovery and circulating progenitor cell mobilization and the toxicity of three cytokine regimens administered after high-dose non-myeloablative chemotherapy with cyclophosphamide 5 g/m2, etoposide 1.5 g/m2 and cisplatin 150 mg/m2. Thirty-five consecutive patients were non-random sequentially allocated to one of three treatment groups: (1) granulocyte colony-stimulating factor alone (n = 15); (2) granulocyte-macrophage colony-stimulating factor alone (n = 10), and (3) sequential interleukin-3 and granulocyte-macrophage colony-stimulating factor (n = 10). Neutrophil recovery in group 1 was significantly hastened as compared to the two other groups (median 2 days, p < 0.005), while no significant differences were observed between groups 2 and 3. CD34+ cells peaked about 2 days earlier in group 1 compared to the other groups (p = 0.0001), whereas the median peak value of CD34+ cells was similar in the three groups. In all patients, the toxicity related to cytokine administration was low and easily manageable with nonsteroidal anti-inflammatory drugs. |
| Databáze: | OpenAIRE |
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