Body composition in heart failure and the impact of cardiac resynchronisation therapy: a proof-of-concept study

Autor: Faizel Osman, Valerie Ansell, Samantha Hyndman, Paul O'Hare, Harpal S. Randeva, Christopher J McAloon
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
Time Factors
heart failure
Pilot Projects
030204 cardiovascular system & hematology
Ventricular Function
Left
Cardiac Resynchronization Therapy
0302 clinical medicine
Natriuretic Peptide
Brain
Natriuretic peptide
Medicine
030212 general & internal medicine
Prospective Studies
Arrhythmias and Sudden Death
Adiposity
medicine.diagnostic_test
Ventricular Remodeling
Atrial fibrillation
Middle Aged
Treatment Outcome
Cardiology
cardiovascular system
Female
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
medicine.drug_class
Proof of Concept Study
03 medical and health sciences
Internal medicine
Plethysmograph
Humans
cardiovascular diseases
Aged
cardiac resynchronisation therapy
body composition
business.industry
Repeated measures design
Recovery of Function
medicine.disease
QP
Peptide Fragments
lcsh:RC666-701
Heart failure
Etiology
Implant
business
Electrocardiography
Biomarkers
RC
Zdroj: Open Heart
Open Heart, Vol 7, Iss 1 (2020)
ISSN: 2053-3624
Popis: AimsBody composition (BC) is known to alter in heart failure. Cardiac resynchronisation therapy (CRT) improves left ventricular geometry but the impact on BC is unknown. Our aim was to evaluate BC in these patients before and after CRT implantation.MethodsProspective proof-of-concept pilot study of heart failure patients undergoing CRT between September 2014 and December 2015. Assessments performed pre-CRT and post-CRT (6 weeks and 6 months) were: BC parameters (using air-displacement plethysmography), New York Heart Failure classification for assessing symptom severity, echocardiography to assess left ventricular geometry, electrocardiography, Minnesota Heart Failure Questionnaire and N-terminal probrain natriuretic peptide (NT-pro-BNP). Repeated measures analysis of variance was performed to assess relative change over time and potential correlations.ResultsTwenty-five patients were recruited; mean-age (±SD) was 73.4±10.0 years, 23 males, 18 CRT defibrillators (remainder CRT pacemakers), 16 had ischaemic aetiology, 6 diabetics, 17 with left bundle-branch morphology on ECG and 10 had atrial fibrillation. Significant inverse correlations were observed in the first 6 weeks following CRT between fat mass and left ventricular end-diastolic volume (r=−0.69, pConclusionThis is the first study to observe interplay between BC and cardiac geometry/function following CRT; a trend in overall fat mass reduction was noted following CRT and merits further study.
Databáze: OpenAIRE
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