Differences in ethanol drinking between mice selected for high and low swim stress-induced analgesia
| Autor: | Kazimierz Jaszczak, Ryszard Pluta, Grzegorz R. Juszczak, Mariusz Sacharczuk, Pawel Lisowski, A Tymosiak-Zielinska, Artur H. Swiergiel, Bogdan Sadowski, Andrzej W. Lipkowski, A Sliwa |
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| Rok vydání: | 2008 |
| Předmět: |
Chronic exposure
Health (social science) Alcohol Drinking Mice Inbred Strains Pharmacology Toxicology Biochemistry Swim stress Eating Mice Behavioral Neuroscience chemistry.chemical_compound Stress Physiological Animals Medicine Swimming Endogenous opioid Ethanol business.industry Alcohol dependence Ethanol drinking General Medicine Opioid system Neurology chemistry Opioid Receptors Opioid Analgesia business medicine.drug |
| Zdroj: | Alcohol. 42:487-492 |
| ISSN: | 0741-8329 |
| Popis: | Alcoholism is a complex disorder, still not fully understood, in which environmental and inherited risk factors play essential roles. Of particular importance may be chronic exposure to stress thought to increase preference for ethanol in genetically susceptible individuals. Animal and human data suggest that the opioid system may be involved in the development of alcohol dependence. We studied the effects of chronic mild stress (CMS) on the voluntary intake of 8% ethanol in the mouse lines displaying high (HA) or low (LA) swim stress-induced analgesia. These lines differ in the activity of the endogenous opioid system. Normally, 8% ethanol is aversive to rodents. We found that LA mice with the low opioid system activity exposed to CMS manifested greater ethanol intake than under no stress conditions. No such effect of CMS on ethanol consumption was observed in HA mice that display the enhanced opioid system activity. We conclude that CMS imposed on individuals with a genetically determined low opioid activity may favor the development of ethanol abuse. |
| Databáze: | OpenAIRE |
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