Successful pseudo-autologous stem cell transplantation for donor-derived Burkitt lymphoma occurring 9 years after allogeneic transplantation

Autor: Shiho Taniguchi, Sae Utsumi, Yu Kochi, Yuki Taya, Yasuo Mori, Yu-ichiro Semba, Takeshi Sugio, Kohta Miyawaki, Yoshikane Kikushige, Yuya Kunisaki, Goichi Yoshimoto, Akihiko Numata, Koji Kato, Naoyuki Uchida, Takahiro Maeda, Toshihiro Miyamoto, Shuichi Taniguchi, Koichi Akashi
Rok vydání: 2022
Předmět:
Zdroj: International Journal of Hematology. 117:287-292
ISSN: 1865-3774
0925-5710
Popis: Donor-derived hematological malignancies have been recognized as rare but serious late complications in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. Most cases in the literature were diagnosed as myelodysplastic syndrome or acute leukemia, with very few malignant lymphoma reported. We herein present another case of donor-derived Burkitt lymphoma that occurred 9 years after allo-HSCT under continued administration of immunosuppressants for chronic graft-versus-host disease (GVHD). The patient achieved a partial response after rituximab-combined intensive chemotherapy. To reduce the risk of relapse and to avoid organ toxicities due to repeated chemotherapies, we performed upfront high-dose chemotherapy followed by stem cell rescue using donor-derived CD34
Databáze: OpenAIRE
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