Expression of Androgen Receptor and Prostatic Specific Markers in Salivary Duct Carcinoma
| Autor: | Chun-Yang Fan, Jianzhou Wang, E L Barnes |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty medicine.drug_class Acid Phosphatase Antiandrogen Pathology and Forensic Medicine Salivary duct carcinoma Immunoenzyme Techniques Prostate medicine Carcinoma Humans Salivary Ducts Aged Aged 80 and over business.industry Carcinoma Ductal Breast Middle Aged Prostate-Specific Antigen Ductal carcinoma Salivary Gland Neoplasms medicine.disease Prostate-specific antigen Carcinoma Intraductal Noninfiltrating medicine.anatomical_structure Prostatic acid phosphatase Receptors Androgen Female Surgery Anatomy Breast carcinoma business |
| Zdroj: | The American Journal of Surgical Pathology. 24:579-586 |
| ISSN: | 0147-5185 |
| DOI: | 10.1097/00000478-200004000-00014 |
| Popis: | Salivary duct carcinoma (SDC) is an uncommon, pathologically distinct entity characterized by its morphologic resemblance to ductal carcinoma of the breast and highly aggressive behavior. Approximately two thirds of patients die within 4 years of initial diagnosis despite aggressive, combined surgical resection and radiotherapy. Review of the literature indicates that androgen receptor (AR), a marker frequently detected in prostatic carcinoma, is expressed in over 90% of SDCs, whereas two common breast carcinoma markers, estrogen and progesterone receptors (ER and PR), are expressed in only 1.3% and 6% of the tumors, respectively, by immunohistochemistry. This hormonal profile suggests that SDC, in contrast to its histiologic similarity to ductal carcinoma of the breast, is immunophenotypically more related to prostatic carcinoma. To substantiate this hypothesis, we performed immunohistochemical staining of 13 cases of SDC for the presence of AR and two prostatic markers, prostate specific antigen (PSA) and prostatic acid phosphatase (PAP). Our results showed multifocal, scattered, moderate immunostaining for PAP and diffuse, moderate immunostaining for PSA in seven (58.3%) and two (16.7%) cases, respectively. These results create a potential diagnostic challenge to surgical pathologists who are dealing with a metastatic adenocarcinoma of AR+/PSA+/-/PAP+/- phenotype, particularly in male patients of unknown primary. Metastatic salivary duct carcinoma should be given serious thought if clinical investigation fails to reveal a prostatic primary. The immunophenotypic homology that exists between SDC and prostatic carcinoma also suggests that antiandrogen therapy as used in the treatment of prostatic carcinoma might be beneficial in patients with metastatic SDC when all other conventional modalities fail. |
| Databáze: | OpenAIRE |
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