Detection and quantification of phenethylamines in sports dietary supplements by NMR approach
| Autor: | Mei Wang, Bharathi Avula, Jianping Zhao, Ikhlas A. Khan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Phenethylamine
Proton Magnetic Resonance Spectroscopy Clinical Biochemistry Pharmaceutical Science Phenethylamines Performance-Enhancing Substances Diosgenin Sports nutrition Oxilofrine 01 natural sciences Analytical Chemistry chemistry.chemical_compound Drug Discovery medicine Humans Food science Spectroscopy Doping in Sports Staining and Labeling 010405 organic chemistry Hordenine 010401 analytical chemistry food and beverages Synephrine Phytosterols Octopamine (drug) Deuterium 0104 chemical sciences Chromatographic separation chemistry human activities medicine.drug |
| Zdroj: | Journal of pharmaceutical and biomedical analysis. 151 |
| ISSN: | 1873-264X |
| Popis: | Phenethylamines (PEAs) are popular substances found in weight-loss and sports nutrition supplements. They are generally pharmacologically active and primarily affect the sympathetic nervous system. Many PEAs are synthetic chemicals and are on the prohibited list of the World Anti-Doping Agency. In this study, nuclear magnetic resonance (NMR) spectroscopy was applied to detect and identify the presence of PEAs in sports dietary supplements without the need for chromatographic separation or pre-knowledge on formulation. Eight PEAs, viz. phenethylamine, synephrine, oxilofrine, hordenine, β-methylphenethylamine, N-methyltyramine, octopamine and deterenol, were identified from 32 dietary supplements sold in the US market. Furthermore, a quantitative NMR method was developed and validated for simultaneous determination of the concentrations of the PEAs. The study demonstrated that NMR could be a potential tool to monitor and detect PEAs or other ingredients in dietary supplements. |
| Databáze: | OpenAIRE |
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