A double-blind, randomized, comparative study evaluating clinical effects of two sequential estradiol-progestogen combinations containing either desogestrel or medroxyprogesterone acetate in climacteric women

Autor: P Jaszczak, A. Saure, H.K Poulsen, Juan Planellas
Rok vydání: 2000
Předmět:
medicine.medical_specialty
Hormone Replacement Therapy
medicine.medical_treatment
Medroxyprogesterone
Administration
Oral
Blood Pressure
Sweating
Medroxyprogesterone Acetate
Gastroenterology
General Biochemistry
Genetics and Molecular Biology
Placebos
03 medical and health sciences
0302 clinical medicine
Double-Blind Method
Internal medicine
medicine
Flushing
Medroxyprogesterone acetate
Humans
Vaginal bleeding
030212 general & internal medicine
Climacteric
Gynecology
030219 obstetrics & reproductive medicine
Desogestrel
Estrogens
Conjugated (USP)
Estradiol
Progesterone Congeners
business.industry
Mood Disorders
Standard treatment
Estradiol valerate
Obstetrics and Gynecology
Hormone replacement therapy (menopause)
Middle Aged
medicine.disease
3. Good health
Menopause
Female
Uterine Hemorrhage
medicine.symptom
business
medicine.drug
Zdroj: Maturitas. 34(2)
ISSN: 0378-5122
Popis: Objectives: The aim of this study was to compare a new sequential estradiol–desogestrel (E2-DSG) hormone replacement regimen (Liseta®) with one of the standard treatments i.e. estradiol valerate–medroxyprogesterone acetate (E2V-MPA) combination (Klimalet®) regarding the alleviation of climacteric symptoms, vaginal bleeding pattern and the occurrence of adverse experiences. Methods: In a multicenter study performed in Denmark, a total of 376 perimenopausal women with climacteric symptoms were randomly allocated to oral sequential treatment with either E2-DSG (1.5 mg E2 for 24 days with 0.15 mg DSG for the last 12 days followed by a placebo tablet for 4 days) (n=186) or with E2V-MPA (2 mg E2V for 21 days with 10 mg MPA for the last 10 days) (n=190). Treatments were administered, using a double-blind, double-dummy technique for 6 cycles of 28 days. Results: Three hundred and seventeen women, 158 in the E2-DSG and 159 in the E2V-MPA group, completed six treatment cycles. Both treatments reduced menopausal symptoms rapidly and to a similar extent. Hot flushes were present in 88% of the women in both groups. After six treatment cycles, hot flushes were no longer present in 71 and 62% of the women in the E2-DSG and E2V-MPA group, respectively. Perspiration decreased from 80 to 65% in the E2-DSG group and from 82 to 63% in the E2V-MPA group. Mood disturbances were present in 82% of the women in the E2-DSG at baseline, and in 52% after six cycles. In the E2V-MPA group the corresponding figures were 68 and 42%, respectively. The bleeding pattern was comparable in both treatment groups. Regular withdrawal (expected) bleeding appeared in 90–92% and in 85–90% of the women in cycles 1–5 with E2-DSG and E2V-MPA, respectively. Irregular bleeding (including spotting) occurred in 15.2% of the women receiving E2-DSG and in 20.1% of the women treated with E2V-MPA in cycle 6. In both treatment groups there was a tendency of a slight decrease in blood pressure. Adverse events were in less than 10% in each group the reason to discontinue treatment. Conclusions: Both treatments effectively alleviated menopausal complaints and presented good cycle control. Bleeding pattern and mood disturbances appeared to be more favorable influenced by E2-DSG.
Databáze: OpenAIRE
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