| Autor: |
Nicolas M. Kouyoumdzian, Gabriel Kim, Gabriel D. Robbesaul, Paula D. Prince, Ana M. Puyó, Belisario E. Fernández, Mónica L. Galleano, Marcelo R. Choi |
| Rok vydání: |
2021 |
| Zdroj: |
Revista Argentina de Cardiologia. 89:98-106 |
| DOI: |
10.7775/rac.es.v89.i4.20034 |
| Popis: |
Introduction: The role of the chloride anion on the deleterious effects of excessive consumption of salt (NaCl) and whether its effects are independent each other of the presence of sodium remains to date, unknown and unclear. Objective: To demonstrate that both a chloride overload and a sodium overload in the diet produce deleterious effects, by different mechanisms, on systolic blood pressure (SBP), renal function and markers of oxidative stress in the kidney. Materials and Methods: Male Wistar rats were divided into four groups (n = 8 / group) and fed with different diets for three weeks: C: control (standard diet), and diets: NaCl: hypersodic-hyperchloric; Na: hypersodic without chloride and Cl: hyperchloric without sodium. Systolic blood pressure (SBP) and renal function were determined, and the production of thiobarbituric acid reactive species (TBARS) and the activity and expression of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) enzymes were evaluated in renal cortex tissue. Results: SBP increased (*) in the two groups fed with chloride. The fractional excretion of sodium and chloride increased (*) in the NaCl and Na groups. increased (*) in the renal cortex with the three diets. No changes were observed in the activity and expression of SOD and CAT. GPx activity increased (*) in the two groups that received chloride; (* p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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