Limited Antibody‐Dependent Cellular Cytotoxicity Antibody Response Induced by a Herpes Simplex Virus Type 2 Subunit Vaccine
| Autor: | Andria G. M. Langenberg, Steve Kohl, Rose E. Sekulovich, Cheryl Goldbeck, Karin Hartog, Edwin D. Charlebois, Rae Lyn Burke, Mavash Sigouroudinia |
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| Rok vydání: | 2000 |
| Předmět: |
Antibody-dependent cell-mediated cytotoxicity
Vaccines Synthetic Cellular immunity Herpes Genitalis biology Herpesvirus 2 Human viruses Immunogenicity Vaccination Antibody-Dependent Cell Cytotoxicity Viral Vaccines medicine.disease_cause Virology Virus Herpesviridae Infectious Diseases Herpes simplex virus Viral Envelope Proteins Immunology Humoral immunity medicine biology.protein Humans Immunology and Allergy Antibody |
| Zdroj: | The Journal of Infectious Diseases. 181:335-339 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | The humoral response to a herpes simplex virus (HSV) type 2 subunit vaccine containing recombinant glycoproteins B (gB 2 ) and D (gD 2 ) was tested in 3 groups of patients. These included HSV-seronegative, HSV-1-seropositive, and HSV-2-seropositive individuals. There were excellent antibody responses, as measured by gB 2 - and gD 2 -specific ELISAs and HSV-2 neutralization assays. However, in 2 HSV-2 antibody-dependent cellular cytotoxicity (ADCC) assays, there were relatively low antibody responses, especially among HSV-seronegative individuals. The low ADCC responses may be associated with the poor efficacy of this vaccine observed in clinical trials. |
| Databáze: | OpenAIRE |
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